Treatment of PAD by Platelet Lysate for Therapeutic Angiogenesis

Status Completed

Clinical Trial Summary

Induction of autologous angiogenesis in patients with critical limb ischemia using platelet lysate.

Clinical Trial Description

Ten male and female patients diagnosed with Peripheral artery disease (PAD), will be recruited. This diagnosis will be based on medical history, physical examinations, laboratory tests, and specific diagnostic tests. Patients qualified for this study, are patients with distal extremity ischemia indicated by claudication and rest pain present for a minimum of 4 weeks without evidence of improvement in response to conventional drug therapy; showed angiographic evidence of PAD in the affected limb; and were not candidates for surgical revascularization. Platelet lysate will be injected intramuscularly at different sites of the gastrocnemius muscle. The purpose of this study is to evaluate the safety and efficacy of platelet lysate injections into ischematic limbs of patients with PAD. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02941419
Study type	Interventional
Source	University of Jordan
Contact
Status	Completed
Phase	Phase 1/Phase 2
Start date	March 5, 2013
Completion date	February 9, 2017

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT03987061` - MOTIV Bioresorbable Scaffold in BTK Artery Disease	N/A
Recruiting	`NCT03668353` - Recombinant SeV-hFGF2/dF Injection for PAOD	Phase 1
Recruiting	`NCT04110964` - Evaluation of Safety and Tolerability of Libella Gene Therapy for Critical Limb Ischemia: AAV- hTERT	Phase 1
Not yet recruiting	`NCT03994666` - Cell Therapy in Critical Limb Ischemia	Phase 2
Recruiting	`NCT02389023` - Comparison of Prevena Negative Pressure Incision Management System vs. Standard Dressing After Vascular Surgery	N/A
Completed	`NCT02539940` - Elutax-SV Drug-eluting Balloons for Below-the-knee Treatment
Not yet recruiting	`NCT02498080` - Drug Eluting Balloons PTA in Infra-popliteal Arteries in Patients With Critical Limb Ischemia	N/A
Recruiting	`NCT02239419` - Evaluation of Carbothera in the Treatment of Foot Ulcers	N/A
Recruiting	`NCT01938872` - Evaluating the Effectiveness of Paclitaxel-eluting Balloons for Below-the-knee Angioplasty in Patients With Critical Limb Ischemia	N/A
Active, not recruiting	`NCT01211925` - Distal Venous Arterialisation of Ischemic Limb	Phase 2/Phase 3
Completed	`NCT02454231` - Monocentric Trial: Stem Cell Emergency Life Threatening Limbs Arteriopathy (SCELTA)	Phase 2/Phase 3
Completed	`NCT01758874` - Study to Explore the Effect of Lowering Blood Viscosity in Patients With Treatment-resistant Critical Limb Ischemia	Phase 2
Completed	`NCT02475200` - Phoenix Post-Approval Registry - Using the Phoenix Atherectomy Systems
Recruiting	`NCT04583436` - Efficacy and Safety Comparison of the Open and Endovascular Surgical Methods for the Treatment of Long Atherosclerotic Lesions of the Femoral-popliteal Segment Below the Knee, TASC D in Patients With Critical Limb Ischemia	N/A
Completed	`NCT04071782` - Investigating the Safety and Efficacy of the Treatment With the Selution Sirolimus Coated Balloon in TASC C and D Tibial Occlusive Disease in Patients With Critical Limb Ischemia From Singapore	N/A
Completed	`NCT03669458` - Feasibility Clinical Trial Using the SPUR System to Demonstrate Safety and Efficacy.	N/A
Not yet recruiting	`NCT06007469` - Pedal Acceleration Time (PAT) as a Measure of Foot Perfusion
Recruiting	`NCT04110327` - An All-Comers Observational Study of the MicroStent™ Peripheral Vascular Stent System in Subjects With Peripheral Arterial Disease
Completed	`NCT02260622` - Pilot Study to Examine the Use of Rivaroxaban After Angioplasty for Critical Limb Ischemia	Phase 2
Recruiting	`NCT02054416` - External Compression Therapy for Secondary Prevention of Lower-Limb Loss and Cardiovascular Mortality	N/A