Critical Illness Clinical Trial
— AKIVEXOfficial title:
VExUS-guided Fluid Management in Patients With Acute Kidney Injury in the Intensive Care Unit
A quasi experimental study that aims to verify whether the incorporation of VExUS in patients with AKI in the Intensive Care Unit (ICU) may prompt tailored interventions to increases the number of days free from Renal Replacement Therapy (RRT) during the first 28 days.
Status | Recruiting |
Enrollment | 55 |
Est. completion date | December 31, 2022 |
Est. primary completion date | December 31, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Non-elective ICU admission - Severe acute kidney injury (AKI) defined either: A = 2-fold increase in serum creatinine from a known pre-morbid baseline or during the current hospitalization OR Urine output < 6.0 mL/kg over the preceding 12 hours Exclusion Criteria: - Life-threatening indication of RRT (defined as intractable hyperkalaemia, acidosis, uraemic symptoms) at Day 0 - RRT before recruitment - Use of Extracorporeal membrane oxygenation (ECMO) - Hepatic cirrhosis or other condition with portal hypertension - Lack of commitment to provide RRT as part of limitation of ongoing life support - Known pre-hospitalization advanced chronic kidney disease, defined by an estimated glomerular filtration rate < 30 mL/min/1.73 m2 or chronic RRT - Refusal to sign the informed consent form |
Country | Name | City | State |
---|---|---|---|
Brazil | Hospital de Clínicas de Porto Alegre | Porto Alegre | Rio Grande Do Sul |
Lead Sponsor | Collaborator |
---|---|
Hospital de Clinicas de Porto Alegre |
Brazil,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Renal replacement therapy | Number of days free from renal replacement therapy during the first 28 days | Day 28 | |
Secondary | Mortality | Day 28 | ||
Secondary | KDIGO category for AKI | Variation in Kidney Disease: Improving Global Outcomes (KDIGO) criteria for AKI after 48 hours. Reducing the KDIGO category is a better outcome. | 48 hours |
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