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Volume Overload clinical trials

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NCT ID: NCT05965934 Recruiting - Heart Failure Clinical Trials

Management of Volume Overload HF Patients by Individual DSR Treatment adJustment-a clinicAl inVestigation of InfusatE2.0

MOJAVE
Start date: July 7, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

This study is a multi-center, prospective, randomized (2:1), open-label study to evaluate the safety and efficacy of DSR therapy using the Infusate 2.0 peritoneal solution (composed of 30% icodextrin and 10% dextrose) in diuretic resistant patients with HF and persistent volume overload.

NCT ID: NCT05735288 Completed - Dialysis Clinical Trials

Haemodialysis Outcomes & Patient Empowerment Study 03

HOPE-03
Start date: February 14, 2023
Phase:
Study type: Observational

This is a prospective, single-arm observational study that aims to assess the validity and reproducibility of an algorithm for assessing fluid status in a cohort of dialysis patients. The study will externally validate an existing algorithm for dry weight prediction in real-time in a cohort of dialysis patients.

NCT ID: NCT05595395 Recruiting - Volume Overload Clinical Trials

The Enteral Resuscitation In Intensive Care Pilot- Study

ERI
Start date: February 13, 2023
Phase: N/A
Study type: Interventional

The purpose of this pilot study is to overcome the limited evidence on enteral fluid administration in intensive care medicine and to generate data for further hypothesis generation in an exploratory setting. This trial is a prospective, multicenter, randomized, parallel group, open-label study to compare the current standard of practice, the intravenous fluid administration, with a more physiological approach, the enteral fluid administration, in critically ill patients.

NCT ID: NCT05240833 Recruiting - Critical Illness Clinical Trials

VExUS-guided Fluid Management in Patients With Acute Kidney Injury in the Intensive Care Unit

AKIVEX
Start date: January 7, 2022
Phase: N/A
Study type: Interventional

A quasi experimental study that aims to verify whether the incorporation of VExUS in patients with AKI in the Intensive Care Unit (ICU) may prompt tailored interventions to increases the number of days free from Renal Replacement Therapy (RRT) during the first 28 days.

NCT ID: NCT05217342 Recruiting - Heart Failure Clinical Trials

PVP-Guided Decongestive Therapy in HF

PERIPHERAL-HF
Start date: January 1, 2022
Phase: Phase 4
Study type: Interventional

The investigators hypothesize that a simple assessment of peripheral venous pressure (PVP) will better predict the diuretic need and long-term outcomes (all cause mortality, all cause rehospitalization, emergency department visits) compared to standard evaluation.

NCT ID: NCT05104528 Completed - Volume Overload Clinical Trials

Non-Invasive Cardiometry and Ultrasound Guided Inferior Vena Cava Collapsibility Index in Assessing Fluid Responsiveness

Start date: September 6, 2021
Phase: N/A
Study type: Interventional

43 patients between 18-60 years presenting with criteria of sepsis (life-threatening organ dysfunction caused by a dysregulated host response to infection, suspected or documented infection and an acute increase ≥2 SOFA [Sequential Organ Failure Assessment] points) will be enrolled in our study. Approval of the ethical committee and informed written consent from first degree relatives will be issued. They will be given a full and detailed explanation of the intended study protocol and will be informed about the potential benefits of the development of a successful technique as well as the potential side-effects. To compare the efficacy of non-invasive cardiometry and ultrasound (US) guided inferior vena cava (IVC) collapsibility when assessing the response of septic patients to fluid therapy guidelines of The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3); in the first six hours of ICU admission .

NCT ID: NCT05070819 Completed - Cardiac Disease Clinical Trials

Atrial Natriuretic Peptide in Assessing Fluid Status

Start date: September 23, 2021
Phase: N/A
Study type: Interventional

Biomarkers can play a significant role in fluid status assessment intraoperatively.

NCT ID: NCT04921319 Recruiting - Sepsis Clinical Trials

De-resuscitation Informed by Ultrasound for Patients With Sepsis

DRI-US
Start date: April 26, 2021
Phase: N/A
Study type: Interventional

Randomized, unblinded clinical trial of 152 critically ill patients with sepsis admitted to the intensive care unit. The primary determine if using the Venous Excess Ultrasound Score (VExUS) to guide fluid deresuscitation in critically ill patients with sepsis reduces net fluid balance at 5 days as compared to usual care.

NCT ID: NCT04882358 Active, not recruiting - Heart Failure Clinical Trials

Safety & Feasibility of DSR TherApy in Heart FAiluRe pAtients With Persistent Congestion

SAHARA
Start date: May 27, 2021
Phase: N/A
Study type: Interventional

Feasibility and safety study of the alfapump DSR system in the treatment of volume overloaded heart failure subjects receiving high doses of loop diuretics. Up to 24 subjects will be enrolled in up to 3 centres in Republic of Georgia, and randomized into 2 parallel treatment arms. Once implanted with the alfapump DSR system they will undergo DSR therapy in 2 phases: intensive treatment phase followed by maintenance treatment phase.

NCT ID: NCT04775576 Completed - Clinical trials for Perioperative/Postoperative Complications

Comparison of Conventional Fluid Management Protocol With Targeted Pleth Variability Index (PVI) Monitoring Protocol During Total Abdominal Hysterectomy and Bilateral Salpingooferectomy Operation

Start date: February 25, 2021
Phase: N/A
Study type: Interventional

This study aims to compare the volume management methods performed by using conventional method and PVI monitoring in intraoperative fluid treatment during bilateral salpingo-oophorectomy and total hysterectomy operation.