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PK/PD and Clinial Outcomes of Beta-lactams in ICU Patients

Critical Illness Clinical Trial

Official title:
Pharmacokinetics/Pharmacodynamics and Clinical Outcomes of β-lactams in Critically Ill Patients

Clinical Trial Summary

Meropenem and imipenem are broad-spectrum carbapenem antibiotic and are frequently prescribed in critically ill patients with severe infections. These patients show several pathophysiological changes that may alter the carbapenem pharmacokinetic (PK) normally found in other populations. Although the PK of carbapenems has been widely studied, most studies have been conducted on small populations, and clinical outcome data are sparse. Therefore, the aims of this study are (i) describe the population pharmacokinetic parameters of meropenem and imipenem in critically ill subject (ii) evaluate the pharmacodynamic of meropenem and imipenem as a predictor of clinical treatment outcome.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03858387
Study type Observational
Source Prince of Songkla University
Contact Sutep o Jaruratanasirikul, M.D.
Phone 6674451485
Email jasutep@medicine.psu.ac.th
Status Recruiting
Phase
Start date September 1, 2018
Completion date December 31, 2021
View Details
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