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Optimization of PK/PD Target Attainment for Ceftriaxone in Critically Ill Patients With Community-acquired Pneumonia.

Critical Illness Clinical Trial

Official title:
Impact op Capillary Leak and Hypoalbuminemia on PK/PD of Ceftriaxone in Critically Ill Patients With Overwhelming Pneumonia

Clinical Trial Summary

WP2.1. PK/PD target attainment Plasma exposure ELF exposure WP2.2. Predictive dosing algorithm WP2.3. ECMO subset

Clinical Trial Description

First, the investigators will document exposure to ceftriaxone in plasma and epithelial lining fluid. Second, the investigators will try to identify risk factors for not attaining PK/PD target. Based on significant predictors for target non attainment a predictive dosing algorithm will be constructed. Finally in a small subset of ECMO patients PK exposure will be explored. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03438981
Study type Observational
Source Universitaire Ziekenhuizen Leuven
Contact
Status Completed
Phase
Start date January 2013
Completion date July 2019
View Details
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