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NCT05279482 Clinical Trial

Comparison Between Different Doses of Steroids in COVID-19 Patients

Critical Illness Clinical Trial

— COVID-19  

Official title:
Comparison Between Standard Dose Methyl Prednisolone and Megadose Methyl Prednisolone as Regards Outcome in SARS.COV.2 Patients in Intensive Care Unit : Retrospective Study

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05279482
Other study ID # MS41/2022
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 19, 2022
Est. completion date March 9, 2022

Study information
Verified date March 2022
Source Ain Shams University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

aim of this study is to compare between standard dose methyl prednisolone and mega dose methyl prednisolone as regards outcome reflected by mortality rate, percentage of mechanically ventilated patients and icu length of stay of covid 19 patients admitted in intensive care unit.

Description:

Retrospective study for comparison between standard dose methyl prednisolone and mega dose methyl prednisolone as regards outcome reflected by mortality rate ,percentage of mechanically ventilated patients and icu length of stay of covid 19 patients admitted in intensive care unit. Previous studies suggested that cytokine release syndrome could be involved in the pathophysiology of critical SARS.COV.2 resulting in death so early suppression of cytokine storm may be lifesaving in critical patients.

Recruitment information / eligibility
Status Completed
Enrollment 104
Est. completion date March 9, 2022
Est. primary completion date March 1, 2022
Accepts healthy volunteers
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - All icu admitted covid 19 patients with positive PCR, diagnosed by CT chest and needing oxygen therapy Exclusion Criteria: - Not requiring oxygen therapy - Negative PCR - Uncontrolled blood sugar or DKA - Patients on long term steroids therapy

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• observation for outcome of methylprednisolone dose
no intervention as it is retrospective study for outcome

Locations
Country Name City State
Egypt Ain shams university hospitals Cairo
Egypt Faculty of medicine, Ain Shams University Cairo

Sponsors (1)
Lead Sponsor Collaborator
Ain Shams University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary 28 days mortality rate observation for mortality rate in both groups 1 month
Secondary mechanical ventilation and icu length of stay observation for percentage of mechanically ventilated patients and length of stay up to 3 months
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