Continuous Passive Paracentesis for Intra-abdominal Hypertension — COPPTRIAHL  

Critical Illness Clinical Trial

Official title: Continuous Passive Paracentesis Versus Large Volume Paracentesis in the Prevention and Treatment of Intra-abdominal Hypertension and Abdominal Compartment Syndrome in the Critically Ill Cirrhotic Patient With Ascites

Status Recruiting

Clinical Trial Summary

Liver cirrhosis patients in Intensive Care present intra-abdominal hypertension and this is an independent risk factor for increased organ disfunction and mortality.

Patients will be randomized into intermittent or continuous passive paracentesis and the clinical results of these two strategies for preventing and treating intra-abdominal hypertension will compared.

Clinical Trial Description

Intra-abdominal hypertension is an independent risk factors for increased mortality in Intensive Care patients and is highly prevalent in the critically ill cirrhotic patient. This study compares two strategies in minimizing intra-abdominal pressure and optimizing abdominal perfusion pressure in the prevention and treatment of intra-abdominal hypertension associated morbidity and mortality. Critically ill cirrhotic patients will be allocated into a standard-of-care large-volume paracentesis group (control) and a continuous passive paracentesis (intervention) group using randomization. Results will assess renal function and multi-organ function using standard clinical scales and vital outcomes. ;

Related Conditions & MeSH terms

• Ascites
• Ascites Hepatic
• Cirrhosis, Liver
• Critical Illness
• Fibrosis
• Hypertension
• Hypertension, Intraabdominal
• Intra-Abdominal Hypertension
• Liver Cirrhosis
• Paracentesis

• NCT number: NCT04322201
• Study type: Interventional
• Source: Centro Hospitalar de Lisboa Central
• Contact: Rui A Pereira, MD, MSc
• Phone: +351 934341322
• Email: rui.m.pereira@chlc.min-saude.pt
• Status: Recruiting
• Phase: N/A
• Start date: November 2, 2019
• Completion date: May 31, 2022