Cow’s Milk Allergy Clinical Trial
Official title:
Oral Tolerance in Cow’s Milk Allergy in the Infant: Role of CD4+CD25+ T Cells and Intestinal Microflora
This study aims to determine if there is a link between cow’s milk allergy in infants and
regulatory T cells dysfunction that should be transient in infant acquiring oral tolerance
after 12 month avoiding food and persistent in others.
Cow’s milk allergy is evaluated by basophils activation test, T cells activation test,
specific humoral response (IgA, IgE, IgG) in allergic infants before and after 12 month
avoiding food, before and after low dose milk exposure, before and after oral challenge.
Number and function of regulatory T cells and microflora composition are measured at the
same time.
Allergic infants are compared to age matched control group.
n/a
Observational Model: Case Control, Time Perspective: Longitudinal