COVID-19 Clinical Trial
Official title:
Paradoxical Response to Chest Wall Loading in Mechanically Ventilated Patients: Incidence, Mechanism, and Novel Techniques for Detecting it at the Bedside
Verified date | November 2021 |
Source | HealthPartners Institute |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purposes of our study are to: 1) determine the incidence of paradoxical response to chest wall loading in mechanically ventilated patients; 2) identify sub-populations in which it is most likely to occur (e.g., severe ARDS); and 3) standard the bedside procedure for demonstrating this physiology.
Status | Withdrawn |
Enrollment | 0 |
Est. completion date | December 1, 2022 |
Est. primary completion date | December 1, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: Non-surgical patients admitted to the ICU at Regions Hospital (St. Paul, MN) or Methodist Hospital (St. Louis Park, MN), receiving mechanical ventilation for any reason, and breathe passively during mechanical ventilation Exclusion Criteria: 1. Age < 18 years old 2. Pregnancy at the time of their inclusionary hospitalization 3. Recent (< 30 days) abdominal or chest wall surgery (including spine) 4. Recent (< 30 days) abdominal or chest wall trauma (including spine) 5. Traumatic brain injury, intracranial bleed, or recent neurologic surgery 6. Family member or representative not available to provide informed consent 7. Not passive while receiving mechanical ventilation support 8. Hemodynamic instability |
Country | Name | City | State |
---|---|---|---|
United States | Regions Hospital | Saint Paul | Minnesota |
Lead Sponsor | Collaborator |
---|---|
HealthPartners Institute |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Lung compliance (mL/mmHg) | Does lung compliance improve (ie, increase) with an intervention (chest wall loading) that decreases chest wall compliance/reduces lung volume. | 20 minutes total in measure duration. |
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