COVID-19 Clinical Trial
— PROVID-CAPNETZOfficial title:
Clinical, Molecular and Functional Biomarkers for PROgnosis, Pathomechanisms and Treatment Strategies of COVID-19 (PROVID) - (PROVID-CAPNETZ)
The pandemic triggered by the new SARS-CoV-2 presents the German health system with previously unknown challenges. There are currently no effective therapies for the treatment of the SARS-CoV-2 lung disease Covid-19. The aim of the joint project PROVID is to draw conclusions from the often very different clinical appearance of infections with the SARS-CoV-2 pathogen in order to improve patient care through targeted clinical management. The effects of infections with the SARS-CoV-2 pathogen are wide-ranging and include a spectrum from symptomlessness to infections of the upper respiratory tract, uncomplicated but also severe pneumonia with lung failure and high mortality. PROVID will first check whether certain host factors determine the severity and / or the course of Covid-19. Research is also being carried out into whether the molecular and clinical values of Covid-19 patients differ from those of patients with pneumonia caused by other pathogens. In addition, it will be tested whether specific molecular markers describe the severity of the disease and are suitable as an aid for targeted therapy for Covid-19. PROVID is an interdisciplinary joint project made up of three sub-projects that are being implemented at three locations (Charitè-Universitätsmedizin Berlin, Universität Leipzig IMISE and CAPNETZ STIFTUNG / Hannover). PROVID is based on three clinical research platforms with a high track record in recruiting patients with high-quality data and biomaterials on the one hand and guideline-changing results on the other hand: CAPNETZ (competence network CAP, since 2002, world's largest database and biobank for CAP), PROGRESS (Pneumonia Research Network on Genetic Resistance and Susceptibility for the Evolution of Severe Sepsis, since 2007) and CAPSyS (systems medicine of community-acquired pneumonia, since 2014). The COVID-19 patients are recruited into 3 different patient cohorts via these 3 research platforms. 1. PROVID-CAPNETZ, 2. PROVID-PROGRESS, 3. PROVID-CAPSyS.
Status | Recruiting |
Enrollment | 400 |
Est. completion date | July 1, 2022 |
Est. primary completion date | January 1, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Age = 18 - Radiological proof of infiltrate (primarily chest x-ray or CT) with positive detection of SARS-CoV-2-virus or with no proven infiltrate with positive detection of SARS-CoV-2-virus - Informed consent signed Exclusion Criteria: - Newly diagnosed, active pulmonary tuberculosis within the last 2 months - Simultaneous participation in PROVID-PROGRESS or PROVID-CAPSyS cohort - Participation of the patient in PROVID-PROGRESS or PROVID-CAPSyS cohort at an earlier point in time |
Country | Name | City | State |
---|---|---|---|
Germany | Krankenhaus Bad Arolsen | Bad Arolsen | |
Germany | Charité - Universitätsmedizin Berlin | Berlin | |
Germany | HELIOS Klinikum Emil von Behring Berlin | Berlin | |
Germany | Vivantes Klinikum Neukölln | Berlin | |
Germany | Carl-Thiem-Klinikum Cottbus | Cottbus | |
Germany | Klinikum Dortmund gGmbH | Dortmund | |
Germany | Universitätsklinikum Dresden | Dresden | |
Germany | Universitätsklinikum Frankfurt | Frankfurt | |
Germany | Klinik Schillerhöhe | Gerlingen | |
Germany | Hannover Medical School | Hannover | |
Germany | Universitätsklinikum Jena | Jena | |
Germany | Krankenhaus der Augustinerinnen | Köln | |
Germany | Universitätsklinikum Schleswig-Holstein Campus Lübeck | Lübeck | |
Germany | Universitätsklinikum rechts der Isar | München | |
Germany | Agaplesion Diakonieklinikum Rotenburg | Rotenburg |
Lead Sponsor | Collaborator |
---|---|
Hannover Medical School | Charite University, Berlin, Germany, University of Leipzig |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Determination of the host- and virusdependent mechanisms associated with the clinical appearence of COVID-19 | Determination of specific molecular markers | up to 1 year | |
Primary | Determination of the course of COVID-19 | Host factors (transcriptional response/RNA, proteins, antibodies) determine the course of COVID-19 | up to 1 year | |
Primary | Determination of the severity of COVID-19 | Host factors (transcriptional response/RNA, proteins, antibodies) determine the severity of COVID-19 | up to 1 year |
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