Covid19 Clinical Trial - Adolescents With COVID-19/MIS-C at HCFMUSP

Status Enrolling by invitation

Clinical Trial Summary

This is a protocol aimed at children and adolescents contaminated with COVID, treated at the Hospital das Clínicas, University of Sao Paulo, Brazil (HCFMUSP), in the recovery phase. The study aims to evaluate the spectrum of pathogenic lesions of the virus not only in the respiratory system, but digestive, immunological, neurological and others. Clinical, evolutionary, laboratory and functional parameters will be used.

Clinical Trial Description

School-age children and adolescents COVID-19 survivors may have persistent inflammation, a chronic course of COVID-19, with isolated or concomitant aggressions of various organs and systems, making this disease a potential chronic condition, impacting aspects of quality of life related to health (HRQoL), physical and mental health. In addition, pediatric COVID-19 can induce autoimmunity (with the possibility of primary hypothyroidism and type I diabetes mellitus), delayed linear growth and delayed pubertal development, secondary immunodeficiency and present genetic polymorphisms in brain plasticity impacting rehabilitation. School-aged children and adolescents with COVID-19 could present muscle weakness, dysautonomy, asthenia and physical inactivity, so it is essential that safe and effective interventions are developed to maintain adequate levels of physical activity and that they can be implemented on a large scale. However, to date, there are no systematic longitudinal studies that have evaluated all these aspects in a pediatric population that survived COVID-19, particularly with chronic conditions and who were hospitalized in a tertiary service. ;

Study Design

Related Conditions & MeSH terms

Communicable Diseases
Corona Virus Infection
Coronavirus Infections
Covid19
Infection
SARS (Severe Acute Respiratory Syndrome)
SARS-CoV Infection
Severe Acute Respiratory Syndrome

Clinical Trial Details

NCT number	NCT04659486
Study type	Interventional
Source	University of Sao Paulo
Contact
Status	Enrolling by invitation
Phase	N/A
Start date	September 24, 2020
Completion date	April 30, 2021

View Details

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