Stress Echocardiography in Patients Recovery From Mild COVID-19 Illness

COVID-19 Clinical Trial

— ECHO-vid  

Official title:

Stress Echocardiography in Patients Recovery From Mild COVID-19 Illness

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04498299
• Other study ID #: Cardiology-004
• Status: Recruiting
• Start date: September 1, 2020
• Est. completion date: November 30, 2020

Study information

• Verified date: July 2020
• Source: Hospital Beneficencia Espanola de Puebla
• Contact: miguel ayala-leon
• Phone: 5529625396
• Email: terapia_intensiva_miguel[@]hotmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

With the appearance of the new SARS-COV2 virus, additional challenges are being imposed on the medical community after the resolution of acute COVID-19 illness, resulting in specific pathophysiologic mechanisms that while acutely damage the lung parenchyma might chronically impact the cardiopulmonary system.

This study aims to investigate changes after mild COVID-19 illness in echocardiographic indices at rest and stress.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: November 30, 2020
• Est. primary completion date: October 1, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Having suffered mild COVID-19 illness

• PCR test negative after COVID-19 illness

• Men or women

• Age =18 years and < 45.

• No history of other cardiovascular or lung disease.

• No cardiovascular risk factors, that is, arterial systemic hypertension, smoking, diabetes, dyslipidemia

• No ongoing or previous cardio or vasoactive treatment

• Able to use the semi-supine exercise bicycle

• Able to give informed consent

Exclusion Criteria:

• Poor acoustic window.

• Tricuspid regurgitation more than mild

• Professional sports activity

• Pregnancy

• Obesity (body mass index [BMI], =30 kg/m2).

• Inability to provide consent

Related Conditions & MeSH terms

• COVID-19
• Echocardiography, Stress
• Hypertension
• Hypertension, Pulmonary

Intervention

Diagnostic Test:
• echocardiogram 2D
The patient is accelerating against a workload that gradually increases at a constant rate during the exercise, images will be obtained by echocardiography. The patient begins with 25 Watts with increments of 25 Watts every 3 minutes, continuing the exercise until significant electrocardiographic changes occur or the patient starts with symptoms.

Locations

Country	Name	City	State
Mexico	Hospital Beneficencia Española de Puebla	Puebla

Sponsors (1)

Lead Sponsor	Collaborator
Miguel Ayala León

Country where clinical trial is conducted

Mexico, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	• LA volume index	Left atrium volume index	3 minutes
Primary	• LV telediastolic diameter	Left ventricle telediastolic diameter	3 minutes
Primary	• LV telesystolic diameter	Left ventricle telesystolic diameter	3 minutes
Primary	• LV posterior wall	Left ventricle posterior wall	3 minutes
Primary	• RA area	Right atrium area	3 minutes
Primary	• RV basal dimensión	Right ventricle basal dimensión	3 minutes
Primary	• RV mid cavity dimension;	Right ventricle cavity dimensión	3 minutes
Primary	• RV longitudinal dimension	Right ventricle longitudinal dimension	3 minutes
Primary	• Distal, RV outflow tract dimension at the distal or pulmonic valve level	Distal, right ventricle outflow tract dimension at the distal or pulmonic valve level	3 minutes
Primary	• Proximal RV outflow tract dimension at the proximal subvalvular level	Proximal right ventricle outflow tract dimension at the proximal subvalvular level	3 minutes
Primary	• TAPSE	• Tricuspid annular plane systolic excursion	3 minutes
Primary	• RV free Wall strain	Right ventricle free Wall strain	3 minutes
Primary	• Inferior cava vein PW Doppler	Inferior cava vein PW Doppler	3 minutes
Primary	• E wave mitral	E wave mitral	3 minutes
Primary	• A wave mitral	A wave mitral	3 minutes
Primary	• E wave /A wave mitral	E wave /A wave mitral	3 minutes
Primary	• E-wave at mitral annulus	E-wave at mitral annulus	3 minutes
Primary	• E-wave at mitral annulus / A-wave at the mitral annulus	E-wave at mitral annulus / A-wave at the mitral annulus	3 minutes
Primary	• E wave/ E-wave at the mitral annulus	E wave/ E-wave at the mitral annulus	3 minutes
Primary	• E tricuspid (E)	E tricuspid (E)	3 minutes
Primary	• A tricuspid (A)	A triuspid (A)	3 minutes
Primary	• E/A	E/A	3 minutes
Primary	• Systolic pulmonary artery pressure	Systolic pulmonary artery pressure	3 minutes
Primary	• E-wave at the tricuspid annulus	E-wave at the tricuspid annulus	3 minutes
Primary	• Mean pulmonary artery pressure	Mean pulmonary artery pressure	3 minutes
Primary	• Stroke volume	Stroke volume	3 minutes
Primary	• Cardiac output	Cardiac output	3 minutes