COVID19 Clinical Trial
Official title:
Assessment of the Effect of Convalescent Plasma Therapy in Patients With Life-threatening COVID19 Infection
- This clinical trial proposal is based on the FDA protocol for emergency use of
convalescent plasma for treatment of COVID-19 cases, and on the WHO guidelines for use
of convalescent plasma in other infectious diseases.
- This Clinical trial is to be applied in Cairo University quarantine hospital. The
collection, testing and storage of convalescent plasma will be done inside CUH main
blood bank.
The concept of this clinical trial is built on the collection of convalescent plasma from
individuals who had recovered from documented infection with SARS-CoV-2, to be used for
patients with- or at high risk of progression to- severe/life-threatening clinical conditions
due to SARS-CoV-2 infection.
An informed consent is required to join this clinical trial; patients will be transfused with
one or two units of ABO compatible convalescent plasma. Those patients will be followed up
and the clinical and laboratory data will be compiled, including adverse events related to
the administration of convalescent plasma (CP).
Other data to be collected retrospectively will include patient demographics, acute care
facility resource utilization (total length of stay, days in ICU, days intubated, and
survival till discharge from an acute care facility).
This study will be done inside Cairo university hospitals, it will involve a number of CP
donors who were recovered from COVID-19 infection and were treated at Cairo University
isolation hospital. The CP donation process will take place at CUH blood bank ,the number of
the donors will be determined at the end of the study as it will vary according to the
donation process .
The study will also include sixty seven /life threatening COVID-19 patients admitted to Cairo
University isolation hospital.
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