COVID-19 Clinical Trial
Official title:
Effect of Natural Food on Gut Microbiome and Phospholipid Spectrum of Immune Cells in COVID-19 Patients
The efficacy of natural foods such as freeze-dried mare's milk (Saumal) in post-COVID syndrome therapy has not been studied. The literature review has shown that researchers have focused more on evidence-based medications and less on natural products. Some raw foods, such as freeze-dried mare's milk, contribute to forming complete immune complexes and have antioxidant, membrane stabilizing, and antiviral effects. The use of Saumal proved its effectiveness in patients suffering from chronic hepatitis C. After 4 weeks of using freeze-dried mare's milk, the biodiversity of the intestinal microbiome was increased. The content of bacteria secreting short-chain fatty acids also increased. The study aims to confirm these effects at the gene level in patients who underwent COVID-19. This study will allow us to develop a highly evidence-based component of rehabilitation therapy in patients after COVID-19.
The study consists of three stages. Stage I. Randomized division of 76 patients under study into a main group of 38 patients receiving Saumal for 4 weeks and a control group of 38 patients not receiving Saumal. All respondents have suffered from COVID-19 in the last 6 months. At the moment of the research, all patients will be staying in rehabilitation centers in Almaty City. The study's biological material will be collected from the respondents (gut microbiome and antiphospholipid antibodies). Stage II. The main group will be given Saumal for four weeks, after which the gut microbiome and antiphospholipid antibodies will be collected from both groups once again. This will allow us to assess the impact of freeze-dried mare's milk on the condition of the gut microbiome and antiphospholipid antibodies. Stage III. Data analysis. 1. Based on the results of gut microbiome sequencing and ELISA (antiphospholipid antibodies) in the main and control groups, we determine the dynamic changes of that parameters during COVID-19 rehabilitation. 2. According to the results, the effectiveness of Saumal itself regarding these 2 parameters will be evaluated. 3. Develop recommendations and an algorithm for patient management after COVID-19 to prevent complications. ;
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