COVID-19 Clinical Trial
— NUEVAOfficial title:
Novel Use of an Existing Vaccine (BCG) Alliance: The NUEVA Trial
Verified date | March 2021 |
Source | Henry M. Jackson Foundation for the Advancement of Military Medicine |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The current COVID-19 epidemic threatens to overwhelm the capacity of many countries to meet their populations' health care needs. Although several vaccines specific for SARS-CoV-2 have been or are being developed, these require testing in animal and human safety studies and they are unlikely to be available during the expected peak periods of the growing epidemic. Two groups at especially high risk of infection and disease are front line health care workers working directly with COVID-19 patients and elderly residents of group homes or facilities that provide skilled nursing care to this frail population. Interim measures to protect these groups while we await a high efficacy vaccine are desperately needed. Based on the capacity of BCG to (1) reduce the incidence of respiratory tract infections in children and adults; (2) exert antiviral effects in experimental models; and (3) reduce viremia in an experimental human model of viral infection, we hypothesize that BCG vaccination may induce (partial) protection against susceptibility to and/or severity of SARS-CoV-2 infection. This study will evaluate the efficacy of BCG to reduce risk of infection by SARS-CoV-2 and mitigate COVID-19 disease severity in at risk health care providers. A phase III randomized controlled trial provides the highest validity to answer this research question. Given the immediate threat of the SARS-CoV-2 epidemic the trial has been designed as a pragmatic study with a highly feasible primary endpoint, which can be continuously measured. This allows for the most rapid identification of a beneficial outcome that would allow other at-risk individuals, including the control population, to also benefit from the intervention if and as soon as it has demonstrated efficacy and safety.
Status | Withdrawn |
Enrollment | 0 |
Est. completion date | March 23, 2021 |
Est. primary completion date | March 23, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 64 Years |
Eligibility | Inclusion Criteria: - Physicians, physician assistants, nurse practitioners, nurses, medics, respiratory therapists and other HCWs who are likely to care for patients with COVID-19 illness - Eligible for care in DoD facilities (DEERS eligible)* - 18-64 years old - Willingness to permit review of medical records - Women of childbearing potential must be willing to use an effective form of birth control for 30 days post vaccination Exclusion Criteria: - Previously (medical history) or currently infected or ill with COVID-19 - Previous TB disease - Fever (>38 C) within the past 24 hours - Currently pregnant or breastfeeding or planning on becoming pregnant within 30 days of enrollment - Current serious underlying medical conditions including: diabetes mellitus, chronic kidney disease, or any other immunocompromising condition: - Known infection by Human Immunodeficiency Virus (HIV) - History of solid organ or bone marrow transplantation - Currently under chemotherapy - Currently on any anti-cytokine therapy - History of immunodeficiency (including history of anti B cell therapy) - Currently taking immunosuppressive drugs - Treatment with oral or intravenous steroids, defined as daily doses of 10mg prednisone or equivalent for longer than 3 months - Active solid or non-solid malignancy or lymphoma within the past two years - Suspicion of active viral or bacterial infection - Living with someone HIV+, who is immunocompromised, or is taking an immunosuppressive drug - Known allergy to (components of) the BCG vaccine or a serious reaction to prior BCG administration - Plan to terminate their employment at the participating health care facility or change duty stations within the next three months - Not in possession of a smartphone - Current participation in a COVID-19 interventional trial |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Henry M. Jackson Foundation for the Advancement of Military Medicine | Harvard Medical School, Immunization HealthCare Division, Defense Health Agency, Uniformed Services University of the Health Sciences, United States Department of Defense |
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* Note: There are 41 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Incidence of symptomatic rt-PCR-confirmed SARS-CoV-2 infection | The primary outcome measure is the development of symptomatic COVID 19 infections. We will use the Cox proportional-hazards model to calculate hazard ratios for the development of COVID-19. This will be reported as the incidence of rt-PCR-confirmed symptomatic SARS-CoV-2 infection following BCG vaccination compared to that following placebo, starting from 3 days post-vaccination through 6 months. | 6 months | |
Secondary | incidence of Serology-confirmed infection with SARS-CoV-2 | The secondary outcome measure is the development of Serology-confirmed infection with SARS-CoV-2. We will use the Cox proportional-hazards model to calculate hazard ratios for the development of COVID-19. This will be reported as the incidence of serology-confirmed SARS-CoV-2 following BCG vaccination compared to that following placebo, starting from 3 days post vaccination through 6 months. | 6 months | |
Secondary | severity of COVID-19 disease | In individuals who test positive for COVID-19, the proportion with severe disease following BCG vaccination compared to placebo, as defined by the following necessary care levels: non- hospital care; patient hospitalized but no oxygen required; hospitalized and oxygen required; patient treated in intensive care and/or on mechanical ventilation; patient died.Additional WHO severity indicators of severe pneumonia, respiratory failure, sepsis, septic shock will also be included. | 6 months | |
Secondary | symptomatic respiratory infection | Incidence of self-reported symptomatic respiratory infections following BCG vaccination compared to that following placebo, starting from 3 days post-vaccination through 6 months. | 6 months | |
Secondary | effect of prior adult immunization with other vaccines associated with trained immunity | rates of 1) all cause respiratory infection 2) symptomatic COVID- 19, 3) serology-confirmed SARS-CoV-2 infection in health care workers. | 6 months |
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