COVID-19 Pneumonia Clinical Trial
Official title:
Pilot Clinical, Statistical and Epidemiological Study on Efficacy and Safety of Convalescent Plasma for the Management of Patients With COVID-19
The health contingency established against the Severe Acute Respiratory Syndrome associated
type 2 Coronavirus (SARS-CoV-2) has promoted a race against the clock for the search on
treatment against the disease related with coronavirus (COVID-19). There are no current
approved therapeutic options against the virus, although there is a rush for the development
of drugs, vaccines and even the passive immunization through plasma from convalescent
patients. This passive immunization is made with the administration of antibodies from
patients that went through the infectious state of the disease and progress to clinical
remission.
SARS-CoV-2, and its predecessor SARS-CoV-1, have great similarities between their genes and
proteins; tis allow to hypothesize that the antibodies developed against SARS-CoV1 can
recognize the antigens of SARS-CoV-2. In this manner, the transfusion of convalescent plasma
to patients with the infection brings the probability on eliminating the infection, in this
case SARS-CoV-2. There are evidence of this phenomenon observed in previous pandemics caused
by SARS-CoV-1, Influenza AH1N1 and Ebola virus.
The objective of the study is to develop a therapeutic strategy based on the administration
of plasma from patients with COVID-19 with clinical remission to patients that are coursing
with the infection. The expected results hopes to establish an effective treatment and
satisfactory recovery of patients with COVID-19. Also, we expect to describe the respective
antibodies related against the SARS-CoV-2 infection.
The health contingency established against the Severe Acute Respiratory Syndrome associated
type 2 Coronavirus (SARS-CoV-2) has promoted a race against the clock for the search on
treatment against the disease related with coronavirus (COVID-19). There are no current
approved therapeutic options against the virus, although there is a rush for the development
of drugs, vaccines and even the passive immunization through plasma from convalescent
patients. This passive immunization is made with the administration of antibodies from
patients that went through the infectious state of the disease and progress to clinical
remission.
SARS-CoV-2, and its predecessor SARS-CoV-1, have great similarities between their genes and
proteins; tis allow to hypothesize that the antibodies developed against SARS-CoV1 can
recognize the antigens of SARS-CoV-2. In this manner, the transfusion of convalescent plasma
to patients with the infection brings the probability on eliminating the infection, in this
case SARS-CoV-2. There are evidence of this phenomenon observed in previous pandemics caused
by SARS-CoV-1, Influenza AH1N1 and Ebola virus.
The objective of the study is to develop a therapeutic strategy based on the administration
of plasma from patients with COVID-19 with clinical remission to patients that are coursing
with the infection. The expected results hopes to establish an effective treatment and
satisfactory recovery of patients with COVID-19. Also, we expect to describe the respective
antibodies related against the SARS-CoV-2 infection.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Suspended |
NCT04901676 -
Leronlimab in Moderately Ill Patients With COVID-19 Pneumonia
|
Phase 3 | |
Not yet recruiting |
NCT04534478 -
Oral Prednisone Regimens to Optimize the Therapeutic Strategy in Patients With Organizing Pneumonia Post-COVID-19
|
Phase 4 | |
Active, not recruiting |
NCT05002517 -
Randomized, Unicentric, Open, Controlled Clinical Trial, in Phase Iii, to Demonstrate the Effectiveness of Tocilizumab
|
Phase 3 | |
Completed |
NCT05008393 -
Efficacy of PJS-539 for Adult Patients With COVID-19.
|
Phase 2 | |
Completed |
NCT04569877 -
GM-CSF Inhalation to Prevent ARDS in COVID-19 Pneumonia
|
Phase 2 | |
Not yet recruiting |
NCT05286255 -
Mesenchymal Stromal Cells for COVID-19 and Viral Pneumonias
|
Phase 1 | |
Completed |
NCT05035589 -
The Effect of Tocilizumab on Procalcitonin and Other Biochemical and Clinical Markers in the Setting of COVID-19 Pneumonia
|
||
Completed |
NCT06113432 -
CPAP Therapy Through a Helmet or a Full Face Mask in Patients With Acute Hypoxemic Respiratory Failure: Cross-over Study
|
N/A | |
Recruiting |
NCT05042063 -
Acoustic Cough Monitoring for the Management of Patients With Known Respiratory Disease
|
||
Recruiting |
NCT04615429 -
Clinical Trial to Assess the Efficacy of MSC in Patients With ARDS Due to COVID-19
|
Phase 2 | |
Completed |
NCT05047653 -
RALE Versus CORADS/CT-Severity Score in COVID-19
|
||
Active, not recruiting |
NCT05047016 -
Study to Evaluate the Dynamic Consent Model Based on the Blockchain-based Clinical Trial Platform METORY
|
N/A | |
Active, not recruiting |
NCT05033847 -
Clinical Trial on Sequential Immunization of Recombinant COVID-19 Vaccine (CHO Cells) and Inactivated COVID-19 Vaccine (Vero Cells) in Population Aged 18 Years and Above
|
Phase 2 | |
Recruiting |
NCT06113757 -
Investigation of Efficacy and Safety of Electrical Signal Therapy Provided by Dr Biolyse® Device in COVID-19 Disease
|
N/A | |
Completed |
NCT05504655 -
N-Acetylcysteine as an Adjuvant Therapy in Critically Ill COVID-19 Patients:
|
||
Active, not recruiting |
NCT05035524 -
A Randomized Controlled Trial to Investigate The Role of Adjuvant Inhalable Sodium Bicarbonate Solution 8.4% in Treatment of COVID-19
|
N/A | |
Completed |
NCT05065879 -
Evaluation of Immunogenicity and Safety of COVID-19 Vaccine (Produced in Beijing) in Patients With Hypertension and/or Diabetes
|
Phase 4 | |
Withdrawn |
NCT04390217 -
LB1148 for Pulmonary Dysfunction Associated With COVID-19 Pneumonia
|
Phase 2 | |
Withdrawn |
NCT04460105 -
Lanadelumab in Participants Hospitalized With COVID-19 Pneumonia
|
Phase 1 | |
Suspended |
NCT04901689 -
Leronlimab in Patients With Coronavirus Disease 2019 (COVID-19) With Need for Mechanical Ventilation or Extracorporeal Membrane Oxygenation
|
Phase 3 |