Covid19 Clinical Trial
Official title:
Antikörperseroprävalenz Und Hintergrundinfektionsrate Von SARS-CoV-2 in Einem österreichischen Schlüsselkollektiv an Arbeitnehmer*Innen
Context: On March 11, the World Health Organization (WHO) announced the current corona virus
disease 2019 (COVID-19) outbreak as a pandemic. The first laboratory-confirmed case of
COVID-19 in Austria was announced on February 27, 2020. Since then, the incidence of
infection follows a gradual increase. Measurements taken by the Austrian government include
travel restrictions, closing of national borders, social distancing, a mandatory use of
facemasks in public, and closing of stores and restaurants. The underlying aim of those
imposed restrictions is to contain the viral transmission and to slow spreading of the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Objectives: The aims of this study are to determine i) how many employees in Austrian trauma
hospitals and rehabilitation facilities have virus specific IgG and IgM antibodies against
SARS-CoV-2, ii) how many are active virus carriers (symptomatic and asymptomatic), iii) how
many employees are in their incubation period during the study period, and iv) to calculate
the SARS-CoV-2 prevalence together with a specific occupation associated infection risk
within the different specifications of health care workers.
Study Design: Open uncontrolled observational cross-sectional study.
Setting/Participants: A total of 4000 employees in 11 Austrian trauma hospitals and
rehabilitation facilities of the Austrian Social Insurance for Occupational Risks (AUVA) will
be invited to participate in the study.
Study Interventions and Measures: An antibody test for SARS-CoV-2 specific IgG and IgM
antibodies, and a RT-PCR test based on oropharyngeal swab samples, as well as
laboratory-based antibody tests using ELISA, will be implemented to ensure protection and
preservation of health in hospital staff and are not part of the study. The tests will be
conducted twice, with approximately two weeks in between testing. The results of the tests
will be used for statistical analysis in this study together with a questionnaire including
questions related to personal health, traveling activities, living situation, as well as
inquiries of symptoms and comorbidities.
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