COVID-19 Pandemic Clinical Trial
Official title:
Hormonal Contributors to Coronavirus SARS-CoV-2 Infection (COV-ENDO)
The goal of this observational study is to measure the changes in the parameters of endocrine function and tissue sensitivity to hormones induced by SARs-CoV-2 infection. The main questions it aims to answer are: - Does SARs-CoV-2 infection causes endocrine dysfunctions? - Does the treatment of the underlying endocrine dysfunctions, improves the clinical outcome or the occurrence of late onset complications of SARs-CoV-2 infection? - Are patients with previously known endocrine diseases more fragile in case of SARs-CoV-2 infection? Participants will undergo blood testing and a physical examination at admission, during hospitalization at discharge and 3 and 6 moths after discharge They results will be compared to those of patients admitted for other reasons in order to assess whether the prevalence of endocrine dysfunctions is increased compared with controls.
The objectives of the study are the following: Primary objectives: 1. to measure endocrine function tests in patients affected by COVID-19, in order to evaluate whether SARs-CoV-2 causes endocrine alterations and whether endocrine diseases/dysfunctions correlate with the severity of SARs-CoV-2 infection and mortality. 2. to evaluate whether genetic variants in the sex-steroid or vitamin D (VDR) nuclear receptors or ACE are more prevalent in patients with SARs-CoV-2 infection than controls. 3. to evaluate whether vitamin D supplementation in subjects with vitamin D deficiency may influence the outcome of SARs-CoV-2 infection 4. To correlate the influence of overweight/obesity/neck circumference with the evolution of SARs-CoV-2 infection Secondary objectives: Correlate the endocrine function tests with patients' age, disease's outcome, markers of inflammation. The identification of endocrine conditions associated with a worse outcome of SARs-CoV-2 infection, would identify significant risk factors to be reduced/prevented in these patients. For example, if endocrine patients will result more fragile in case of infection, we could systematically screen some parameters and early treat associated defects in order improve the outcome of SARs-CoV-2 infection. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05197634 -
The Impact of Covid-19 Pandemic On The Children With Autism Spectrum Disorder
|
||
| Recruiting |
NCT05918939 -
UNAIR Inactivated COVID-19 Vaccine as Heterologue Booster (Immunobridging Study)
|
Early Phase 1 | |
| Completed |
NCT05383560 -
Safety and Immunogenicity of Omicron Variant-Matched Vaccine Booster in Adults
|
Phase 2 | |
| Active, not recruiting |
NCT05125874 -
Clinical Study for Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01) Booster Immunization
|
N/A | |
| Completed |
NCT05517148 -
Effects of an Immersive Virtual Reality Intervention Combined With Mindfulness-based Stress Reduction
|
N/A | |
| Completed |
NCT05552989 -
Towards Better Preparedness for Future Catastrophes - Local Lessons-learned From COVID-19
|
||
| Completed |
NCT05543551 -
Effects of Diagrammatic Breathing With and Without Resistance in Post Covid Patients on ADLs
|
N/A | |
| Active, not recruiting |
NCT06272253 -
UNAIR Inactivated COVID-19 Vaccine INAVAC as Heterologue Booster (Immunobridging Study) in Adolescent Subjects
|
Early Phase 1 | |
| Active, not recruiting |
NCT05585567 -
A Preliminary Exploratory Study to Evaluate the Safety and Immunogenicity of Omicron Variant Bivalent Vaccine V-01-B5
|
Early Phase 1 | |
| Active, not recruiting |
NCT05582746 -
COVID-19 Testing and Vaccine Literacy for Women With Criminal Legal System Involvement
|
N/A | |
| Not yet recruiting |
NCT05381883 -
Mental Health of Professionals of the Silver Economy of New Aquitaine : Online Survey of Accommodation Establishments for Old People and Home Assistance Establishments
|
N/A | |
| Recruiting |
NCT05062681 -
RCT on the Efficacy of Dexamethasone Versus Methyl Prednisolone in Covid-19 Infected Patients With High Oxygen Flow
|
Phase 4 | |
| Completed |
NCT04697030 -
Burnout Among Adolescent Population During Covid-19 Lockdown in Pakistan
|
||
| Active, not recruiting |
NCT05419167 -
STEP-COVID: A Program for Pregnant Women During the SARS-CoV-2 Pandemic
|
Phase 1 | |
| Terminated |
NCT05553964 -
SARS-CoV-2 OTC At Home Test
|
N/A | |
| Completed |
NCT05596032 -
Prospective Study to Validate the Diagnostic Performance of IVD CAPSULE COVID-19-NP Test for the Detection of SARS-CoV-2
|
||
| Completed |
NCT05583812 -
A Study of FB2001 for Inhalation in Healthy Chinese Adults
|
Phase 1 | |
| Completed |
NCT05844410 -
Evaluation of Corticosteroids Use and Clinical Outcomes in Hospitalized COVID-19 Patients: A Retrospective Study
|
||
| Completed |
NCT05123573 -
Self-Perceived in Medical Students Undergoing Distance Learning
|
||
| Completed |
NCT05305300 -
A Phase I Study to Evaluate Safety, Tolerability, and Immunogenicity of a PIKA COVID-19 Vaccine in Healthy Individuals
|
Phase 1 |