There are about 3709 clinical studies being (or have been) conducted in Thailand. The country of the clinical trial is determined by the location of where the clinical research is being studied. Most studies are often held in multiple locations & countries.
This study aims to compare outcomes of short leg cast and foot cast for treatment acute fifth metatarsal fracture (Zone II).
The purpose of the study is to evaluate safety and immunogenicity of inactivated poliomyelitis vaccine based on Sabin strain (LBVC) in healthy infants to select optimal dose of LBVC as well as to demonstrate the lot-to-lot consistency and non-inferiority of LBVC.
This study was designed to determine the most effective and tolerable dose at the shortest dosing regimen of the investigational drug KAF156 in combination with a solid dispersion formulation of lumefantrine (LUM-SDF) in adult/adolescent and pediatric patients with uncomplicated Plasmodium falciparum malaria. There is unmet medical need for anti-malarial treatment with new mechanism of action to reduce probability of developing resistance, and for duration shorter than 3 days of treatment and/or reduced pill burden.
This Phase 3/4, randomized, observer-blind, multi-center study, stratified study evaluated the immune (antibody) response, efficacy and safety of a cell-derived quadrivalent subunit influenza virus vaccine (Seqirus QIVc) in comparison with a non-influenza comparator, meningococcal serogroup A, C, W-135, and Y (Menveo®, GlaxoSmithKline Biologicals, S.A.) in healthy pediatric subjects ≥2 Years to <18 Years of Age
The investigators will do the Goal directed fluid therapy by protocolized fluid management in the experimental group, using PPV to guide the fluid administration, compare with standard fluid management in patients undergoing complex spine surgery.
The prospective study set forth to test Thai version CPOT and BPS for validity, reliability, and practicality. After translation, both pain scales were tested for concurrent validity, discriminant validity, criterion validity, and inter-rater reliability in patients who were intubated during the postoperative period. Opinions regarding practicality were elicited via questionnaires from nurses who had been using and were familiar with these two pain scales.
(Subproject 1) "Plantar heel pain (PHP)" or "plantar fasciitis" is one of the major foot problems which can occur in any age group. It is a commonly encountered musculoskeletal problem that can cause disability, activity limitation, discomfort, and affect the quality of life. It involves pain and inflammation of the plantar fascia, which runs across the bottom of the foot and connects the heel bone to toes. PHP frequently found in active workers aged between 25 and 65 years with the highest incidence in people aged between 40 and 60 years. However, very few studies investigated the alterations of the multisegmental foot motions and muscle functions in patients with PHP. To prescribe the relevant program of treatment and reduce the risk of symptoms chronicity, it is necessary to have an in-depth understanding of changing mechanisms in patients with PHP. To explain how the symptoms occur in patients with PHP, foot function is another aspect that should be determined. One of the popular questionnaires determining foot function is the Foot Function Index (FFI) questionnaire. It has been proved to have good reliability and validity and has been translated into several languages. To be able to use the international standard questionnaire, it is necessary to translate the FFI into Thai. This can be implemented in Thailand and be able to compare the findings of the interventional effect internationally. In addition, very few studies reported the effectiveness of the treatment program for patients with PHP. Among previous evidences, the controversial findings existed. Thus, the intervention program should be evaluated for obtaining the effective treatment for this population. (Subproject 3) The objectives of the study will be General Objective is to investigate the effectiveness of strengthening exercise program on symptoms in patients with plantar heel pain. Specific Objectives is to compare the effectiveness between physical therapy treatment program with strengthening exercise and with stretching exercise on foot function score, pain at worst score, plantar fascia thickness, muscles strength, ankle motion, and gait parameters in patients with plantar heel pain among baseline, after 4th and 8th of treatments, and after 1st and 2nd month of self-home based exercise.
The sensorimotor disturbance and postural instability have been demonstrated to be associated with neck pain. Specific therapeutic exercise and manual therapy for the cervical spine are effective interventions for improving dizziness symptoms, neck impairments, functional ability and quality of life. However, the effects of these interventions on the actual impairment of joint position sense and balance remain uncertain. Adaptive changes in the sensorimotor and postural control systems may need to be specifically addressed.
This study is designed to examine the incidence of postoperative nausea and vomiting during 24 hours after elective laparoscopic cholecystectomy in patients receiving preoperative intravenous fluid loading (group F), ondansetron (group O) and receiving neither fluid nor ondansetron or control group (group C).
Surgical site infection (SSI) is a serious operative complication that may be associated with any surgical procedures. It increases morbidity and mortality after cardiac surgery. Plasma concentration of prophylactic antibiotic, routinely cefazolin, is altered by effects of cardiopulmonary bypass. This study is conducted to measure the plasma concentrations of cefazolin to determine its adequacy in pediatric patients undergoing elective cardiac surgery with cardiopulmonary bypass including its correlation with the incidence of postoperative SSI.