There are about 3285 clinical studies being (or have been) conducted in Pakistan. The country of the clinical trial is determined by the location of where the clinical research is being studied. Most studies are often held in multiple locations & countries.
The purpose of the study is to evaluate whether bemnifosbuvir (BEM) is effective and safe in adults with COVID-19 who do not need to be in the hospital but who are at high risk for progression to severe disease. Eligible subjects will be randomly assigned (by chance) to receive BEM or matching placebo orally for 5 days. Co-administration of locally available standard of care (SOC) is allowed. The total duration of the study is 60 days.
The goal of this study is to compare the three dimensional root resorption after extraction space closure in two groups: two step retraction and en masse retraction. Th main aim of this study is to conclude which method is less damaging to the roots. Participants will be divided into two groups: 1. En masse retraction (experimental) 2. Two step retraction (control) Pre retraction and post retraction CBCT scans will be compared for both groups.
Neck pain is considered one of the very common cause of musculoskeletal pain. It is 4th leading cause of disability with a prevalence ranges between 30% and 50% among general population. cervical pain is among 5 most contributing factors in causing years lived with disability. Mechanical neck pain is identified by neck pain that gets evoked by sustained neck postures, neck mobility and by the palpation of cervical muscles. diagnosis is made through history and physical examination and can be helpful in differentiating from other causes of neck pain. functional impairments suffered by mechanical neck pain patients include weakness of deep cervical flexors, because of activation of superficial cervical muscles, reduced mobility of cervical spine, development of forward head posture, altered proprioception and disturbed balance leading to functional disability and decline in health related quality of life. there are different treatment approaches that include pharmacotherapy, manual therapy, active exercises, stretching, traction and electrotherapy. physiotherapy is often the first line treatment approach for individuals with mechanical, idiopathic and insidious neck pain but manual therapy is preferred through its biomechanical and neurophysiological responses that eventually leads to reduction in pain and improved function in clinical practice.thoracic manipulation and kinesio taping has proved to be very effective in treating mechanical neck pain patients according to several studies despite of their certain limitations. this study aims at evaluating effects of kinesio taping combined with thoracic manipulation in mechanical neck pain patients.
Pelvic girdle pain is the frequently occuring pregnancy-related musculoskeletal condition.It is defined as the pain experienced between the posterior iliac crest and the gluteal region, particularly in the sacroiliac joint.This condition is associated with difficulties in activities of daily life such as standing, walking, working and sleeping hence affecting the quality of life.Various management strategies including antenatal exercises, sacro iliac joint belt, kinesiotaping, sacro iliac joint mobilization etc are used for treating the pelvic girdle pain.Different studies have shown the positive results of antenatal exercises, sacro iliac joint belt and kinesiotaping on the pelvic girdle pain but there is lack of data available to establish the efficacy of sacro iliac joint mobilization on pregnancy-related pelvic girdle pain.So this study aims tofulfill this gap by comparing the effects of antenatal exercises with sacro iliac jpint mobilization on pelvic pain, function and disability in pregnancy-related pelvic girdle pain
Neck pain ranks as the 4th leading cause of disability, with high prevalence of mechanical neck pain in young population. As high as 30% of %. Individuals suffering from neck often report difficulty in performance of daily life, absence from work and decreased productivity. Several manual therapy treatment approaches are used for mechanical neck pain. The focus of this study is to compare the effectiveness of thrust and non-thrust thoracic manipulation for the treatment of mechanical neck pain in young population
Fibromyalgia is a rare musculoskeletal condition worldwide.This condition has a significant impact on the person's quality of life by affecting their various activities of daily living. It is a chronic illness characterized by persistent and widespread non-inflammmtory musculoskeletal pain. Various management strategies including both pharmacological and non-pharmacological are used for the treatment of fibromyalgia. In the recent years strength training and flexibility training are being used for the treatment of fibromyalgia. Strength training is used to improve muscle strength, endurance , power or a combination of both, whereas flexibility training is used to improve ability of a joint to maintain the movement. Different studies have shown postive results of strength training and flexibility training in patients with fibromyalgia. However no such study has investigated the combined effects of both theses techniques. So this study aims to investigate the effect of strength training and flexibility training according to the guidelines of FITT protocol.
Coronary artery bypass grafting (CABG) is one of the common procedure used in coronary artery disease patients which has significant impact on cardiopulmonary and musculoskeletal systems. In the past, phase 1 rehabilitation after procedure focus on cardiopulmonary system. Lower limb rehabilitation is also important part as it influence the cardiac function. Several studies work on post-CABG patients to improve cardiopulmonary fitness but there is less number of data on calf muscles rehabilitation in post-CABG patients. So this study aims to increase the calf muscle extensibility using post-isometric relaxation technique and static stretching.
Low back pain is amongst the most prevalent musculoskeletal conditions worldwide.This condition has a significant impact on the person's quality of life by effecting their various activities of daily living. As of 2017 it remains the leading cause of years lived with disability.Various management strategies are used for the treatment of low back pain. In the recent years neurodynamic techniques are being used for the treatment of low back pain. Escpecially, patients of low back pain who have neural mechanosensitivity may benefit from neural mobilization techniques. Slump stretching is a neurodynamic technqiue which is used to improve the mobility of dural tissue.Different studies have shown postive results of slump stretching in patients of low back pain. However no such study has investigated the role of slump stretching in improving range of motiion in low back pain patients.So this study aims to investigate the the effect of slump stretching in low back pain patients specially on low back Low back pain is amongst the most prevalent musculoskeletal conditions worldwide.This condition has a significant impact on the person's quality of life by effecting their various activities of daily living. As of 2017 it remains the leading cause of years lived with disability.Various management strategies are used for the treatment of low back pain. In the recent years neurodynamic techniques are being used for the treatment of low back pain. Escpecially, patients of low back pain who have neural mechanosensitivity may benefit from neural mobilization techniques. Slump stretching is a neurodynamic technqiue which is used to improve the mobility of dural tissue.Different studies have shown postive results of slump stretching in patients of low back pain. However no such study has investigated the role of slump stretching in improving range of motiion in low back pain patients.So this study aims to investigate the the effect of slump stretching in low back pain patients specially on low back
Neck pain has a global prevalence of 30%, being the fourth leading cause of disability among general population and is more prevalent among females than males, as per concluded by evidence. It is undoubtedly the need of time, to address its proper treatment and to hinder its recurrence amongst the general population. The current physical therapy management of neck pain is more focused towards achieving the short term goals for the patient rather than addressing and amending the actual cause of its relapse. Manual Myofascial Release is one of the very effective treatment used to release soft tissue and fascial adhesions over the myofascia inorder to relieve chronic neck pain. The study aims to compare this manual treatment against Instrument Assisted soft tissue mobilization in order to determine which of the two provides improved outcome in terms of pain, neck disability and cervical Range of motion.
The aim of this study to determine the Comparative effect of active release technique and muscle energy technique on pain, ROM and functional disability in adhesive capsulitis patients with trigger points.