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NCT ID: NCT03564847 Recruiting - Depression Clinical Trials

Learning Through Play (LTP) Plus Intervention for Depressed Fathers (LTP Plus Dads)

LTP Plus Dads
Start date: June 1, 2018
Phase: N/A
Study type: Interventional

The aim of the study is to evaluate the clinical and cost effectiveness of culturally adapted group parenting intervention delivered by non-specialists and community health workers for depressed fathers.

NCT ID: NCT03564652 Not yet recruiting - Clinical trials for Undernutrition, Lactation, Fortified Balanced Energy-protein Supplementation

Nutritional Support for Lactating Women and Azithromycin to Infants - Maamta Lactating Women Trial

MaamtaLW
Start date: July 15, 2018
Phase: N/A
Study type: Interventional

A community-based, randomized control, assessor blinded trial in peri-urban settings of Karachi, Pakistan to study the impact of balanced energy-protein dietary supplement, a locally produced ready-to-use nutritional product named 'Maamta', for lactating women (LW) and single prophylaxis dose of Azithromycin for infants, on growth of infants over the period of six months since birth compared to current standard of care. LW and her infant will be enrolled in the trial within 72 hours of the birth and LW will be randomized in either of the arm: 1. Arm A: 'Control Arm', LW will only receive standard of care which comprises of standard nutritional counseling, key messages of exclusive breastfeeding, essential newborn and infant care and immunization. 2. Arm B: 'Maamta only', LW randomized in this arm will receive Maamta product for next 6 months to be consumed in a dose of 2 sachets of 75 grams per day. Further, LW will also receive standard of care which comprises of standard nutritional counseling, key messages of exclusive breastfeeding, essential newborn and infant care and immunization. 3. Arm C: ''Maamta plus Azithromycin', LW randomized in this arm will receive Maamta product for next 6 months to be consumed in a dose of 2 sachets of 75 grams per day. Further, the infant of LW will receive a single dose of Azithromycin (20mg/kilogram) at day 42 of age. Further, LW will also receive standard of care which comprises of standard nutritional counseling, key messages of exclusive breastfeeding, essential newborn and infant care and immunization. This study is aimed to assess the efficacy of a fortified balanced energy-protein supplementation intake for at least 6 months during lactation and exclusive breastfeeding, in improving breast milk composition over the period of six months and length velocity as a primary outcome. Secondly, to assess the efficacy of a fortified balanced energy-protein supplementation intake for at least 6 months during lactation and exclusive breastfeeding in improving breast milk composition over the period of six months, along with oral Azithromycin at 42 days of age to the infant as a single dose to evaluate the impact on length velocity as the primary outcome. Further, this study will also look at the comparison in weight velocity, length-for-age, weight-for-length, and weight-for-age Z scores as secondary outcome at 6 months of age among three arms.

NCT ID: NCT03540927 Enrolling by invitation - Depression Clinical Trials

Problem Management Plus for Entrepreneurs

Start date: June 20, 2018
Phase: N/A
Study type: Interventional

Conflict and unrest over three decades has resulted in significant economic decline in Khyber Pakhtunkhwa (KP) and Federally Administered Tribal Areas (FATA) of Pakistan and these now rank among the poorest regions in the country. The 2009-10 insurgency and subsequent security operations affected both regions and displaced an estimated 2 million people. The severe damage to infrastructure and livelihoods negatively impacted the social and economic fabric of the entire region. As peace has returned to the area, the Economic Revitalization of KP and FATA (ERKF) project, established in 2012 and supported by the World Bank, is working for the rehabilitation of small and medium enterprises (SMEs), with the aim of creation and restoration of jobs. This support is in the form of grants given to individuals who use the funds to establish and run a business in their locality. Epidemiological studies from the area have shown high rates of common mental disorder (eg., depression, anxiety) in the general population (Husain et al, 2006, Khan et al 2016). Such conditions have a serious impact on the well-being, functioning and productivity of affected individuals (World Health Organization, 2000). For example, in the USA, Depressive Disorders have been estimated to cost the economy over US$210 billion per annum, largely due to reduced productivity (Greenberg et al, 2015). The economic rehabilitation of a population exposed to a humanitarian crisis, and therefore at greater risk of depression, must include interventions to reduce mental morbidity so the individuals are able to function better and potentially improve their long-term productivity. The Human Development Research Foundation, in collaboration with the World Bank, has adapted a 5-session group intervention from WHO Problem Management Plus program, tailored to the needs of small and medium enterprise owners affected by the prolonged conflict in KP and FATA areas of Pakistan. This intervention (Problem Management Plus adapted for entrepreneurs) is based on established cognitive behavioral strategies previously tested in Pakistan (Rahman et al, 2016). The goal of the intervention is to improve psychological capital,reduce psychosocial distress leading to, increased productivity in the long-term. The intervention will be evaluated using a two arm, single blind randomized controlled trial.

NCT ID: NCT03513315 Recruiting - Heat Clinical Trials

Heat Emergency Awareness and Treatment (HEAT)

HEAT
Start date: November 30, 2016
Phase: N/A
Study type: Interventional

Investigators propose an intervention trial of a comprehensive education and treatment bundle designed to reduce morbidity and mortality associated with heat-related illness for low resource settings. Two set of interventions will be developed each for emergency department and for community/home. These interventions will be developed by an internal expert group and will be customized and implemented at the home and emergency department (ED) levels, will include evidence-based educational training guidelines for ED health providers as well as educational messages targeting home and community in Karachi, Pakistan.

NCT ID: NCT03510741 Not yet recruiting - Schizophrenia Clinical Trials

Sodium Benzoate and/or N-Acetylcysteine Added to TAU in Patients With Early Schizophrenia Spectrum Disorder.

Start date: June 1, 2018
Phase: Phase 2
Study type: Interventional

This study aims to determine if the addition of Sodium Benzoate and / or NAC to TAU will be acceptable and tolerable and result in overall improvement of symptoms, social and cognitive functioning in patients with early schizophrenia spectrum disorder.

NCT ID: NCT03508999 Recruiting - Gingivitis Clinical Trials

Effectiveness of Metronidazole Gel and Mobile SMS Reminders on Gingivitis in Orthodontic Patients

Start date: May 23, 2018
Phase: Phase 4
Study type: Interventional

A rapid deterioration in oral hygiene occur after bonding of orthodontic appliances. Zachrisson and Zachrisson have reported that even after maintaining excellent oral hygiene, patients usually experience mild to moderate gingivitis within 1-2 months after orthodontic appliance placement. Slutzkey and Levin have reported a prevalence of 72 % gingivitis in orthodontic patients. The difficulty in maintenance of oral hygiene and inefficient removal of supragingival plaque due to the appliances lead to development of gingivitis and hyperplasia. Tooth brush access to the buccal surface of the teeth becomes problematic and predisposes plaque buildup around the brackets. Investigators are now focusing on the development of localized drug delivery systems that can allow maximum concentration on the target site, thus minimizing the potential systemic effects. Metronidazole has been used by several researchers due to its selective antimicrobial activity against the obligate anaerobes. The topical administration in gel form has several advantages. Miani et al concluded that the use of metronidazole gel significantly reduces the total bacterial count in the gingival crevicular fluid. In medicine and dentistry, active mobile telephone short-message service (SMS) reminders have been used to improve patient compliance and positive behavior changes. A study conducted by Epprighta et al have reported the effectiveness of SMS reminder in orthodontic patients. They have reported significantly lower bleeding, gingival and plaque indices scores in SMS reminder group as compared to control. Rationale: The application of metronidazole gel is effective in management of gingivitis in patients undergoing orthodontic therapy. Additionally, the constant reminder therapy at weekly interval would also lead to improvement in the oral hygiene. According to pertinent literature survey, none of the study has been conducted to compare the effectiveness of SMS reminders and use of anaerobic gel to reduce gingival inflammation. Null Hypothesis: Application of 0.8% metronidazole gel and mobile telephone short-message service oral hygiene reminders is equally effective in reducing the gingival inflammation in orthodontic patients with gingivitis as compared to control group. Objective: The objectives of the study will be to assess the use of topical gel or mobile telephone short-message service oral hygiene reminders can reduce gingivitis in orthodontic patients as compared to control group.

NCT ID: NCT03506919 Recruiting - Clinical trials for Treatment of Arthritis

Comparative Clinical Efficacy and Safety of Coded Polyherbal Medicine for the Management of Arthritis

Start date: January 1, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

This study aimed to develop two poly herbal capsule formulations for arthritis through granulation and conduction of their clinical trial in order to achieve quality, efficacy and safety. Arthritis is a chronic disease of unknown cause. An inflammatory disease of the synovium, it results in pain, stiffness, swelling, deformity and, eventually, loss of function in the joints. Despite early detection, current treatment medications are limited in their efficacy and are frequently toxic. Many patients look for complementary and alternative medicine (CAM) options in coping with this debilitating disease. Research has indicated that people suffering from chronic pain, as in arthritis, and those dissatisfied with current treatment are very likely to seek alternative treatments, and an estimated 60-90% of persons with arthritis use complementary and alternative medicines. Among the most widely used treatments are chiropractic and herbal therapies. This growing interest in alternative medical practices clearly indicates the need for more thorough investigation into the safety and efficacy of herbal medicine. Thousand years of traditional use can provide us with valuable guidelines to the selection, preparation and application of herbal formulation. To be accepted as viable alternative to modern medicine, the same vigorous method of scientific and clinical validation must be applied to prove the safety and effectiveness of a therapeutical product.

NCT ID: NCT03506269 Completed - Menopause Clinical Trials

Perception and Knowledge About Menopause Among Pakistani Woman

Start date: January 1, 2018
Phase:
Study type: Observational

This study is conducted to find out perception and knowledge about Menopause among Pakistani Woman.

NCT ID: NCT03506152 Completed - Sepsis Clinical Trials

Evaluation of Serum Procalcitonin in Critically Ill Patients With Suspected Sepsis

Start date: January 1, 2014
Phase:
Study type: Observational

Procalcitonin is a promising marker of sepsis in critically ill patients. Procalcitonin have better diagnostic accuracy compared to White blood cell count and C - reactive protein. Investigators propose that adding Procalcitonin to the list of standard laboratory work up of critically ill patients with suspected sepsis could increase diagnostic accuracy leading to better patient care.

NCT ID: NCT03499184 Recruiting - Clinical trials for Chronic Periodontitis

Adjunctive Probiotics in Chronic Periodontitis

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

This study will assess clinical and microbiological efficacy of probiotics and antibiotics in patients of chronic periodontitis as an adjunctive to scaling and root planing (SRP) in reducing bacterial count and in improving clinical periodontal parameters over the period of 12 weeks.Also the comparison between these adjunctives will be made for clinical assessment clinical periodontal parameters will be taken .these parameters plaque index (PI), gingival index (GI), clinical attachment loss (CAL) and pocket probing depth (PPD) for microbiological assessment plaque sample will be taken, DNA will be extracted and then sample will be processed through quantitative polymerase chain reaction (qPCR) for quantitative analysis of bacterial count of porphyromonas gingivalis.