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NCT ID: NCT03766061 Completed - Clinical trials for Paraumbilical Hernia

Onlay Mesh Hernioplasty Vs Sublay Mesh Hernioplasty for Paraumblical Hernia Repair

Start date: January 1, 2017
Phase: N/A
Study type: Interventional

It is a randomized controlled trial in which we are comparing onlay mesh hernioplasty with sublay mesh hernioplasty for paraumblical hernia.

NCT ID: NCT03765268 Completed - Inguinal Hernia Clinical Trials

Neurectomy Vs Nerve Sparing in Open Inguinal Hernia Repair

Start date: January 1, 2017
Phase: N/A
Study type: Interventional

It is a randomized controlled trial in which we are treating inguinal hernia patients with mesh hernioplasty and either neurectomy of iliohypogastric nerve and ilioinguinal neurectomy or preservation comparing post operative acute or chronic pain

NCT ID: NCT03765086 Completed - Pilonidal Sinus Clinical Trials

Karydakis Procedure Vs Limberg Flap in Treatment of Sacrococcygeal Pilonidal Sinus

Start date: August 1, 2017
Phase: N/A
Study type: Interventional

This study will be a randomized controlled trial in which we will be comparing the effectiveness of Karidakis procedure VS Limberg flap in treatment of sacrococcygeal pilonidal sinus

NCT ID: NCT03763981 Completed - Perianal Fistula Clinical Trials

Comparison of Prolene Thread Seton Vs Silk Thread Seton for the Treatment of Perianal Fistula

Start date: September 1, 2017
Phase: N/A
Study type: Interventional

It is a randomized control trial in which we will treat the patients with perianal fistula with seton placement. We will divide the patients in two groups. Group I will be treated with silk seton and Group II will be treated with prolene setone. The outcome will be then followed as fistula healing and recurrence.

NCT ID: NCT03763383 Completed - Flap Necrosis Clinical Trials

Lateral Arm Flap Usage as Pedicle and Free Flap

Start date: January 1, 2012
Study type: Observational

Abstract Introduction For local reconstruction on upper extremity or as a distant micro vascular flap Lateral arm free flap is an excellent source of tissue with the advantages including short operation time, thin pliable tissue, non-dominant vessel and minimal donor site morbidity, it fulfills the goal of an optimal reconstruction of form, function, and aesthetics .Here the investigator share his experience of lateral arm fasciocutaneous flap, investigator found it effective in covering defects secondary to trauma, malignancy and burns. Methods A retrospective data analysis was done to analyze our usage of lateral arm flap. This included patient's age, sex, primary problem, area involved, size of the flap and outcome of the flap 3 weeks post operatively. For free flaps this also included the recipient artery used for anastomosis and the number of veins anastomosed. Results There were 21 flaps done over a period of five years. This included 11 free flaps and 10 pedicle flaps. Average size of free flap was 12x5 cm and that of pedicle flap was 8x5 cm. In the free flap group, there was failure in 2 flaps both of which were due to arterial anastomoses in zone of injury. In the pedicle flap group however, there were no failures. Conclusion Lateral arm flap is a reliable flap with consistent anatomy that can be used for coverage in different parts of the body.

NCT ID: NCT03762421 Not yet recruiting - Anxiety Clinical Trials

Improving Psychological Well-being of Trainee Civil Servants in Pakistan

Start date: November 30, 2018
Phase: N/A
Study type: Interventional

Political and civil instability in Pakistan has placed many segments of society under stress. A 5-session group intervention incorporating principles of stress management, problem solving, behavioural activation, peer-support and adaptive leadership has been developed and successfully piloted for business professionals working under stressful conditions in Pakistan. The aim of this study is to evaluate the effectiveness of an adapted version of the intervention in improving psychological well-being amongst a group of trainee civil servants in the country. A two-arm single blind, randomised controlled trial of the group intervention will be conducted among trainee civil servants in Pakistan. The participants are newly inducted civil servants (n=240) undergoing a 6 months' induction training. The participants will be randomised on a 1:1 allocation ratio (120 in each arm), with the intervention arm receiving the group intervention integrated into their orientation sessions and the control arm receiving orientation sessions alone. Outcome assessments will be conducted immediately post-intervention and 3 months after the completion of the intervention. The primary outcomes will be change in the prevalence of psychological distress as measured by Patient Health Questionnaire-9 (PHQ-9) and improvement in coping strategies as measured by Brief Cope Questionnaire. Secondary outcomes include symptoms of anxiety (measured by Generalized Anxiety Disorder scale (GAD-7)), well-being (measured by WHO5 well-being index) and psychological capital (measured by Psychological Capital Questionnaire). The primary analyses will be intent-to-treat consisting of all participants included, according to the groups in which they will be randomized. The primary analysis will involve comparing pre to post changes in prevalence of psychological distress and coping strategies of the participants randomly assigned to the two conditions, using Fisher's exact test. Primary analyses will be non-parametric tests; however sensitivity analyses will use parametric models such as linear and logistic regression to control for baseline values of the participants' characteristics. Ethical principles of voluntary informed consent, maintaining anonymity and confidentiality, data management and storage will be followed.

NCT ID: NCT03757923 Recruiting - Hyperandrogenism Clinical Trials

Comparison of Metformin and Pioglitazone in Regulating Menstrual Irregularities and Hyperandrogenism

Start date: June 18, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

To compare metformin with pioglitazone in improving menstrual irregularities and hyperandrogenism in women with PCOS so that an alternate and better treatment option will be available for hyperinsulinemia in pcos patients.

NCT ID: NCT03755648 Completed - Cerebral Palsy Clinical Trials

Effect of Delorme Resistance Exercises Versus Treadmill Training in Cerebral Palsy

Start date: July 20, 2018
Phase: N/A
Study type: Interventional

Cerebral palsy is one of the most important source of disability among children and its incidence is almost 3.6 in thousand live births.Children with Cerebral Palsy presents with ambulatory difficulties.The current study highlights the effect of treadmill training as compared to DeLorme resistance exercises on locomotor activities in cerebral palsy child.The present study would add to the clinical knowledge of physical therapists by promoting the implementation of treadmill training and DeLorme resistance exercises for this prevalent pediatric neurodevelopmental disorder. The study would decrease the burden of disease among community and enhance the social participation of cerebral palsy children. This in turn would improve the quality of living of these disabling diseased children.

NCT ID: NCT03753542 Active, not recruiting - Chemotherapy Effect Clinical Trials

Effect of Nurse-led Education on Parent's Anxiety and Depression on Managing Side Effects of Chemotherapy

Start date: September 6, 2018
Phase: N/A
Study type: Interventional

ABSTRACT Background: Today, a wide range of pediatric cancers is treated by chemotherapy. More than 21 side effects of chemotherapy have been identified. Among those nausea; vomiting, infection and anemia are most common. The adverse effects are normally managed by the parents at home. Ineffective coping and lack of knowledge about chemotherapy side effect management leads parents stress. Contemporary research evidence that Nurse-led education, booklet providence and follow up about chemotherapy and side effect management, help to decrease parents anxiety and depression. Objectives: To measure the effect of nurse-led multimedia education, booklet providence and telephonic follow up about chemotherapy and side effects management on parents anxiety and depression of children receiving chemotherapy for the first time. Methodology: A randomized control trial will be conducted in the department of chemotherapy at Indus Children Cancer Hospital Karachi from March 2018 to August 2018 on parents of children below 18 years of age undergoing chemotherapy for the first time. Total 100 parents will be randomly divided into Intervention group (n=50) and Control Group (n=50). The Intervention group will received multimedia education, booklet and weekly tele-nursing follow-up about chemotherapy and side effects management. The Control group will receive routine care. Parent's anxiety and depression will be identified by using DASS-21 and generalized estimating estimation will be used to analyzed the data. Keywords: Nurse-led, Multimedia education, Booklet, telephonic follow-up, chemotherapy, side effects, parents, anxiety, depression, children, cancer

NCT ID: NCT03747471 Not yet recruiting - Diabetes Clinical Trials

Conversation Map and Diabetes in Pakistan

Start date: November 12, 2018
Phase: N/A
Study type: Interventional

Background Diabetes is recognized as an important cause of premature death and disability. Non-clinical interventions play an important role in the control of diabetes and the prevention of its associated complications. Traditional methods of educating diabetic patients to empower them for the control of their disease might not work in the developing world. However, the novel interactive and pictorial health education tool named Diabetes Conversation Map (DCM) might be effective for the improvement of diabetes management self-efficacy and distress among diabetic patients in lower middle income setting of Karachi, Pakistan. Objective To assess the effectiveness of DCM as compared to routine care to improve the diabetes management self-efficacy (DMSE) and diabetic distress (DD) among type 2 diabetic patients (T2DM) visiting diabetic clinics of tertiary care hospitals in lower middle income setting of Karachi, Pakistan. Methodology This will be a two arms randomized controlled trial, conducted in two tertiary care hospitals, Karachi. A sample of 120 T2DM patients of age 30 - 60 years with sub-optimal diabetes control will be screened through eligibility criteria and diabetes distress screening tool. Patients who fulfill the eligibility criteria and have diabetes distress will be randomized into intervention (n=60) and control group (n=60) using sealed envelopes. The intervention arm will receive four diabetic education sessions using the DCM in a group of 5-8 participants and each session will be at the interval of one (1) week, by the principal investigator. T2DM patients in the controlled arm will receive routine care. Data on DMSE and DD will also be measured 2-3 months post intervention after the completion of all education sessions. Descriptive statistics will be used for data analysis through SPSS version 20; whereas, application of Repeated Measures ANOVA will be carried out for inferential statistics.