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NCT ID: NCT01636817 Terminated - Clinical trials for Rheumatoid Arthritis

A Trial of NNC0109-0012, an Anti-IL-20 Biologic, in Patients With Active Rheumatoid Arthritis Who Are Inadequate Responders to Anti-TNFa Biologics

Start date: August 2012
Phase: Phase 2
Study type: Interventional

This trial is conducted in Europe, North America and South America. The aim of this trial is to investigate the clinical efficacy of NNC0109-0012, a human monoclonal antibody, compared to placebo when administered as weekly s.c. (subcutaneous, under the skin) injections to patients with active rheumatoid arthritis (RA) who are inadequate responders to anti-TNFa biologics and are on a stable background of methotrexate (MTX) therapy.

NCT ID: NCT01635218 Completed - Moderate Depression Clinical Trials

Homeopathic Treatment for Depression in Peri- and Postmenopausal Women

HOMDEP-MENOP
Start date: March 2012
Phase: Phase 2
Study type: Interventional

The aim of this study was to determine whether individualized homeopathic treatment and fluoxetine are more efficient than placebo for moderate to severe depression in peri- and postmenopausal women.

NCT ID: NCT01633489 Recruiting - Clinical trials for Lysosomal Acid Lipase Deficiency

Lysosomal Acid Lipase (LAL) Deficiency Registry

ALX-LALD-501
Start date: December 31, 2012
Phase:
Study type: Observational [Patient Registry]

This is an observational, multi-center, international disease registry designed to collect longitudinal data and create a knowledge base that will be utilized to improve the care and treatment of patients with LAL Deficiency. Participation in the Registry by both physicians and patients is voluntary.

NCT ID: NCT01633112 Terminated - Clinical trials for Relapsing-remitting Multiple Sclerosis (RRMS)

MS Study Evaluating Safety and Efficacy of Two Doses of Fingolimod Versus Copaxone

ASSESS
Start date: August 9, 2012
Phase: Phase 3
Study type: Interventional

The purpose of this study was to demonstrate that at least one dose (0.5 mg followed by 0.25 mg) of fingolimod is superior to glatiramer acetate 20 mg SC in reducing the ARR up to 12 months in patients with relapsing-remitting MS

NCT ID: NCT01631565 Completed - Lung Neoplasms Clinical Trials

Early Incorporation of Patient and Family to Attention and Care Program in Oncology Versus Standard of Care

PACO
Start date: May 2012
Phase: Phase 3
Study type: Interventional

There is recent evidence that early palliative care administered to patients helps for their quality of life (QoL). It is however not part of the standard multidisciplinary treatment. This study intents to evaluate the effect of early palliative care in patients with advanced Non-Small Cell Lung Cancer (NSCLC) compared to the standard of care.

NCT ID: NCT01631448 Completed - Clinical trials for Postoperative Infection

Fibrin Based Adhesive for the Prevention of Surgical Complications in the Kidney Transplantation

Start date: May 2010
Phase: Phase 3
Study type: Interventional

Globally there have been about 45,000 kidney transplants last year. Currently, the overall survival of renal transplant receptors is 95% in the first year and 85% at 5 years. A major challenge to overcome by the renal transplant surgeons, are surgical complications which may impact on patient morbidity and mortality, as well as graft function. The aim of the study is to assess whether application of fibrin seal prevents postoperative complications in patients undergoing kidney transplantation. Controlled clinical trial with single-blind evaluation in patients surgically intervened kidney transplantation. It will include all patients undergoing renal transplantation in this Medical Center, any gender and over than 16 years and under 60 years.

NCT ID: NCT01631305 Completed - Clinical trials for Euthyroid Sick Syndrome

Levothyroxine for Children With Euthyroid Sick Syndrome

Start date: January 2012
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine whether levothyroxine is effective and safe in the treatment of children with euthyroid sick syndrome, hospitalized in a pediatric intensive care unit.

NCT ID: NCT01631214 Completed - Clinical trials for Postmenopausal Women With Osteoporosis

Study to Determine the Efficacy and Safety of Romosozumab in the Treatment of Postmenopausal Women With Osteoporosis

ARCH
Start date: May 4, 2012
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine if treatment is effective in preventing fractures in women with postmenopausal osteoporosis.

NCT ID: NCT01630291 Completed - Dry Eye Clinical Trials

The Effect of Electrical Stimulation on Tear Production

Start date: July 2012
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate whether electrical stimulation of the nerve innervating the tear gland results in tear production in subjects with severe Dry Eye.

NCT ID: NCT01628705 Completed - Clinical trials for Nutritional and Metabolic Disease

Moderated-fat Diet Complemented With Green Tea Reduces oxLDL and Fat Mass in Obese Women

GTRoxLDL
Start date: April 2007
Phase: Phase 4
Study type: Interventional

Background: Obesity is a chronic degenerative disease, considered as cardiovascular risk factor, characterized by systemic inflammation and high levels of oxLDL. Clinical studies have suggested that drink green tea could improve these complications. Objective: Analyze the effect of a moderate-fat diet complemented with green tea on oxLDL, fat mass and TNFa in obese women. Design: Randomized, controlled clinical trial. Obese women, without other chronic-degenerative disease were divided using a computer-generated random sequence: control group (CON) with n=32, and intervention group (INT) with n=32; and were instructed to consume a moderate-fat diet, and INT group was instructed to complement the diet with green tea. Anthropometric and biochemical measurements were performed, and oxLDL and TNFa s levels were determined by ELISA. All parameters were realized at baseline and in the 1st, 2nd and 3rd months post-intervention. TNFa mRNA expression was determined by real-time RT-PCR (basal and final). The changes on lipid profile, oxLDL, fat mass and TNFalpha expression were reported of the comparison between basal and final time points. The statistical analysis was performed with SPSS software.