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NCT ID: NCT02586155 Completed - Clinical trials for Coronary Artery Disease

Effect of RVX000222 on Time to Major Adverse Cardiovascular Events in High-Risk T2DM Subjects With CAD

BETonMACE
Start date: November 2015
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether bromodomain extraterminal domain (BET) inhibition treatment with RVX000222 in high-risk type 2 diabetes mellitus patients with coronary artery disease increases the time to major adverse cardiovascular events.

NCT ID: NCT02585960 Completed - Hemophilia A Clinical Trials

BAX 855 PK-guided Dosing

PROPEL
Start date: November 23, 2015
Phase: Phase 3
Study type: Interventional

1. To compare the efficacy and safety of pharmacokinetic (PK)-guided treatment with BAX 855 targeting FVIII trough levels of 1-3% and approximately 10% (8-12%) 2. To further characterize pharmacokinetic (PK) and pharmacodynamic (PD) parameters of BAX 855

NCT ID: NCT02585258 Completed - Clinical trials for RheumatoId Arthritis

The Glucocorticoid Low-dose Outcome in RheumatoId Arthritis Study

Gloria
Start date: June 30, 2016
Phase: Phase 4
Study type: Interventional

Comparing the cost-effectiveness and safety of additional low-dose glucocorticoid in treatment strategies for elderly patients with rheumatoid arthritis: The Glucocorticoid Low-dose Outcome in RheumatoId Arthritis Study (GLORIA)

NCT ID: NCT02584959 Completed - Clinical trials for Hereditary Angioedema (HAE)

Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1 Esterase Inhibitor for the Prevention of Angioedema Attacks in Adolescents and Adults With Hereditary Angioedema

Start date: November 1, 2015
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the efficacy and safety of subcutaneous administration of a liquid formulation of C1 esterase inhibitor for the prevention of angioedema attacks in adolescent and adult subjects with hereditary angioedema.

NCT ID: NCT02581995 Completed - Macular Edema Clinical Trials

Investigation of the Change of Vision-related Quality of Life in Subjects Treated With Aflibercept According to EU Label for DME.

AQUA
Start date: November 19, 2015
Phase: Phase 4
Study type: Interventional

To evaluate the change in quality of life (NEI VFQ 25) in subjects with DME during the first year of treatment with aflibercept according to the EU Label.

NCT ID: NCT02581891 Completed - Clinical trials for Macular Degeneration

Managing Neovascular (Known as "Wet") Age-related Macular Degeneration Over 2 Years Using Different Treatment Schedules of 2 mg Intravitreal Aflibercept Injected in the Eye

ARIES
Start date: November 19, 2015
Phase: Phase 4
Study type: Interventional

This study aims to evaluate the optimal use, efficacy, and safety of a Treat-and-Extend regimen with aflibercept in subjects with nAMD.

NCT ID: NCT02580591 Completed - Clinical trials for Diabetes Mellitus, Type 1

Empagliflozin as Adjunctive to Insulin Therapy Over 26 Weeks in Patients With T1DM (EASE-3)

Start date: December 22, 2015
Phase: Phase 3
Study type: Interventional

The study will investigate the efficacy, safety, tolerability and Pharmacokinetic(PK) of 3 doses of empagliflozin compared with placebo over 26 weeks in 960 patients with type 1 diabetes mellitus as adjunctive therapy to insulin

NCT ID: NCT02580058 Completed - Ovarian Cancer Clinical Trials

A Study Of Avelumab Alone Or In Combination With Pegylated Liposomal Doxorubicin Versus Pegylated Liposomal Doxorubicin Alone In Patients With Platinum Resistant/Refractory Ovarian Cancer (JAVELIN Ovarian 200)

Start date: December 21, 2015
Phase: Phase 3
Study type: Interventional

A Phase 3 global study comparing avelumab alone to avelumab plus PLD and to PLD alone to demonstrate that avelumab given alone or in combination with PLD is superior to PLD alone in prolonging Overall Survival in patients with platinum resistant/platinum refractory ovarian cancer.

NCT ID: NCT02578095 Completed - Hip Fractures Clinical Trials

Acute Hip Fracture Study in Patients 65 Years or Greater

Start date: October 30, 2015
Phase: Phase 2
Study type: Interventional

This is a randomized, double-blind, parallel group, placebo-controlled, multicenter study to investigate the safety, tolerability, and efficacy of VK5211 after 12 weeks of treatment. Males and females ≥65 years old who are ambulatory and recovering from a hip fracture will be eligible for participation 3-7 weeks post-injury.

NCT ID: NCT02576717 Completed - Multiple Sclerosis Clinical Trials

A Multi-Site, Open-Label Extension Trial of Oral RPC1063 in Relapsing Multiple Sclerosis

Start date: October 16, 2015
Phase: Phase 3
Study type: Interventional

The purpose of the trial is to determine the safety and efficacy of RPC1063 in patients with relapsing multiple sclerosis.