There are about 3753 clinical studies being (or have been) conducted in Hong Kong. The country of the clinical trial is determined by the location of where the clinical research is being studied. Most studies are often held in multiple locations & countries.
To improve secondary school students' positive attitudes towards older adults with physical disabilities via a Promoting an incLUsive Society towards older adults with physical disabilities through disability simulation education (PLUS) project.
The main objective of this study is to evaluate the pharmacokinetics (PK) of a single dose of Olpasiran in Chinese participants with elevated serum lipoprotein(a) (Lp[a]).
Pruritus is defined as an unpleasant sensation of the skin that provoke the desire to scratch or rub. Its presence is an essential diagnostic feature. According to some European studies, 91% of patients with Atopic Dermatitis report suffering from pruritus at least once daily. And 58.1% of them experience chronic pruritus, leading to great deterioration in quality of life. Various internal and external factors may trigger pruritus. Mediators secretion such as keratinocyte-derived Thymic Stromal Lymphopoietin (TSLP) and Nerve Growth Factor (NGF) could activate nerve fibres which will eventually transmit signals to the brain causing the sensation of itching. Although being one of the major annoying symptoms faced by patients with Atopic Dermatitis, effective anti-itching treatments are not available. There is no consistent evidence that topical antihistamines can relief itch. Recently, a new spray named Atoderm 'SOS' is developed. The skin relief technology (by ambora extract and Epigallocatechin gallate (EGCG), associated to enoxolone) claimed to inhibit the release TSLP and NGF which eventually could reduce nerve signals to the brain for itchy feelings. Therefore, our group would like to test the efficacy of this proprietary anti-itch product with our paediatric patients using a wait-list approach as a control. It is aimed to demonstrate that the using the Atoderm 'SOS' spray topically whenever necessary can reduce the unpleasant itchy Atopic Dermatitis's symptom, improve quality of life, as well as to reduce the need for topical treatment.
Patellofemoral pain is a common disease, and it often couples with patellar malalignment. Previously, imbalance of the different quadriceps muscle heads was believed to be a causative factor of patellar malignment. However, findings from electromyography studies on quadriceps activities and patellar alignment in the last two decades were inconsistent. In order to better understand the relationship between quadriceps muscle imbalance and patellar malalignment, shear wave elastography (SWE), which can measure the passive and active muscle stiffness, may shed some new lights to this area. This study aims to examine whether the quadriceps muscle stiffness can predict the patellar position. The healthy young adult will be recruited in this study. Active and passive quadriceps muscle stiffness will be measured with the SWE in different conditions and the result will be correlated with the patellar position measured with magnetic resonance imaging (MRI). Also, electromyography (EMG) activity will be measured during the active stiffness measurement so as to establish the level of agreement between the EMG and SWE data. Linear regression will be used to calculate the relationship between different factors. The total number of subjects needed will be 55 by setting an effect size of 0.15 with two predictors, 80% power, and α at 0.05 in the linear regression. This project will be conducted at PolyU campus and an MRI clinic in Hong Kong. Hopefully, it could be started in July 2021 and will last for 1 year.
Hong Kong is facing an increasing threat of non-communicable diseases (NCDs), which is compounded by population aging. In 2016, 25,771 registered deaths (approximately 55%) were attributed to NCDs. In addition, NCDs caused 104,600 potential years of life lost before 70 years of age. WHO has identified four major behavioral risk factors - tobacco use, harmful use of alcohol, an unhealthy diet, and physical inactivity - that contribute substantially to NCDs and can increase the risk of death. Most premature deaths from NCDs are preventable via lifestyle modification. Therefore, helping people adopting healthy lifestyle practices, such as having a balanced diet and engaging in irregular physical activity, and quitting health-risk behaviors, such as smoking and harmful use of alcohol can help prevent NCDs and improve the quality of life and overall health of the population. However, many people are unmotivated or find it difficult to modify their risk behaviors, despite their awareness of the associated health hazards.
This study aims to test and compare the effectiveness of three priming interventions on consumers' selection of sustainable foods: priming with environmental benefits, health benefits and co-benefits (environment and health benefits).
The purpose of this study was to investigate whether nurses who did mindful coloring for at least five working days during a 10-day period experienced stress reduction afterwards.
Introduction. Sleep problems are a health issue worldwide. Based on the Person-Environment-Occupation-Performance model and the theory of occupational balance, we developed an occupation-based sleep program to address several objectives by lifestyle intervention: 1) minimize the influence of bodily function on sleep; 2) promote an environment conductive to sleep; and 3) restructure daytime activity with a focus on occupational balance through psychoeducation and lifestyle coaching. Method. This study aims to evaluate the effectiveness of an occupation-based sleep intervention on sleep pattern, mood, and occupational balance among community-dwelling adults with insomnia when compared with other, more usual, forms of treatment, typically focused on education, sleep hygiene, and relaxation. A total of 42 subjects were recruited: 22 for the intervention group and 20 for the treatment as usual group.
This will be a randomized control trial (RCT) to examine whether the three priming interventions (health priming, environmental sustainability priming, and co-benefits priming) work to change consumers' sustainable food choice through their effects on changing consumers' emotional reaction when seeing foods with cues of environmental sustainability, which will be indicated by measuring consumers' facial expression, eye movement and pupil dilation.
Project Objective: Parent management training (PMT), which focuses on teaching parents about effective discipline technique using a behavioral approach, has strong evidence base for promoting parent-child relationship, and reducing parental stress and children behavioural problem. Many PMTs, such as the Incredible Years and Triple P program, have been rated as well-established interventions for behavior problems in children. In recent years, the application of mindfulness in the parenting context is emerging. Parental mindfulness was found to have positive effects on parent-child relationship quality and parenting stress. In particular, preliminary evidence of the eight-week mindfulness based intervention for parents, the Mindful Parenting (MP) program was found to reduce parental stress, and to decrease externalizing and internalizing problems in children. The two lines of parenting intervention have different theoretical background but they yield similar positive effect in parents and children. The current study has the following objectives: 1. To explore the similarities and differences of PMT and MP in terms treatment outcome. Outcome measures include parenting knowledge, parent's mindful awareness, parents' emotional competence, positive and negative parenting practice, parental stress,parent-child relationship, and parents' mental health, including parental stress, parents' sense of competence, as well as child behavioural problem 2. To explore the underlying mechanisms for the effectiveness of PMT and MP, including their similarities and differences, and 3. To examine for whom are PMT and MP more effective. Hypotheses In terms of treatment outcome, it is hypothesized that: H1a) When compared to the waitlist control group, both PMT and MP programmes are similarly effective in reducing negative parenting behaviours and behavioural problems in children, promoting positive parenting behaviours, and enhancing parent-child relationship and parents' mental health. H1b) Looking into the different aspects of parenting behaviours, however, PMT has stronger effects than the MP programme on increasing proactive parenting and the use of positive reinforcement, and reducing lax control. By contrast, the MP programme has stronger effects than the PMT on enhancing warmth and supportiveness and reducing parental hostility. In terms of mechanisms of change, it is hypothesized that: H2a) The PMT and MP programmes both have positive effects on parents' mental health by way of improved parenting practices, and such effect is mediated by the reduction in child behavioural problems and improvement in parent-child relationship. H2b) The PMT and MP programmes are different in how they bring about improved parenting practices. Parenting knowledge is the mediator between the PMT programme and improved parenting practices, whereas parent's emotional competence is the mediator between MP programme and improved parenting practices. Lastly, in terms of the effectiveness for particular target participants, it is hypothesized that: H3) PMT is less effective for parents with low emotional competence whereas the MP programme is more effective for parents with low emotional competence.