There are about 21071 clinical studies being (or have been) conducted in Spain. The country of the clinical trial is determined by the location of where the clinical research is being studied. Most studies are often held in multiple locations & countries.
Injuries to the lower limbs are the most common in rugby and within the lower limbs, the most common are those that affect the ligaments of the knee. That is why we will try to improve knee stability and quadriceps strength. The aim of this study is to evaluate the effectiveness of performing a pre-workout exercise protocol to improve knee stability and quadriceps strength in rugby players. Randomized controlled study, simple blind and with follow-up. 30 semi-professional rugby players will be randomized to the two study groups: experimental (pre-training exercise protocol that will include continuous running, squats, and squats and monopodal jumps) and control (without intervention). The intervention will last 4 weeks, with 2 weekly sessions of 15 minutes each. The study variables will be: knee stability (Y-Balance) and quadriceps strength (Single leg hop). The sample distribution will be calculated using the Kolmogorov-Smirnov test. The changes after each evaluation will be analyzed with the t-student test and with an ANOVA of repeated measures, the intra and intersubject effect will be observed. The effect size will be calculated using Cohen's formula. It is expected to see improvement in knee stability and quadriceps strength in athletes who performed the exercise protocol, after the study period.
The objective of plyometric exercises is to improve the range of mobility of the ankle, as well as decrease the stiffness of this joint and increase the strength in the sural triceps, by improving the explosive elastic force. The objective of the study is to assess the efficacy of plyometric exercises in increasing ankle mobility and increasing strength in the sural triceps, in professional female basketball players aged 18 to 40 years. Randomized, simple blind clinical study. 48 basketball players will be randomized to the two study groups: experimental (they will perform the Counter Movement Jump (CMJ) and Drop Jump (DJ) exercises) and control (they will follow their usual routine). The intervention will last 4 weeks, with 2 weekly sessions of 15 minutes each. The study variables will be: range of dorsal flexion movement of the ankle (goniometry) and strength of the sural triceps (My Jump 2). A descriptive statistical analysis will be performed calculating the main statistical characteristics. The sample distribution will be analyzed with the Kolmogorov-Smirnov test. The changes after each evaluation will be analyzed with the t-student test for related samples and with the ANOVA test of repeated measures the intra and intersubject effect will be observed. Cohen's formula will be used to calculate the effect size. It is intended to observe improvement in the range of dorsal ankle flexion movement and strength in the sural triceps.
Limited ankle functionality is one of the main causes of runner injuries. The use of flossing techniques are used to improve functionality. The administration of an expectation can modulate corticospinal excitability, improving the therapeutic response. The objective of the study is to evaluate the effect of inducing a positive expectation along with the application of flossing on the ankle functionality in healthy amateur runners. Randomized clinical study, single blind, with follow-up period. 20 runners will be randomized to the two study groups: experimental (flossing technique with a positive expectation) and control (flossing technique with a neutral expectation). The study variables will be: dorsal ankle flexion (Weigh Bearing Lunge Test), isometric force in plantar ankle flexion (dynamometry), elastic-explosive force (Countermovement Jump) and stability (Y Balance Test). Using a Shapiro-Wilks analysis, the sample distribution will be calculated. The changes after each evaluation will be analyzed with the t-student test of related samples and through an ANOVA of repeated measures the intra and intersubject effect will be observed. The effect size will be calculated using Cohen's formula. It is expected to obtain changes in the variables between both groups and in the group / time interaction, which suggest an effect of the expectation on corticospinal excitability in healthy athletes.
1541/5000 The aim of the Bulgarian squat is to improve the hamstring strength and the stability of the knees, thus reducing asymmetries in the lower limbs. It consists in achieving greater strength and stability of the lower limbs to adapt the athlete to the demands of training and competitions as safely as possible. The main objective of the study is to assess the effectiveness of the Bulgarian squat, in the improvement of asymmetries in lower limbs; improving hamstring strength and knee stability. Randomized, simple blind clinical study. 30 soccer players will be randomized to the study groups: experimental (Bulgarian squats) and control (non-intervention team routine). The treatment will last 4 weeks, with 2 weekly sessions of 10 minutes each. The study variables will be: lower limb strength (vertical jump with the My Jump 2 application), lower limb stability (Y ™ -Balance test) and lower limb asymmetries (Triple Hop Test, Single Hop Test for Distance and Functional Movement Screen) The normality of the sample will be calculated using the Kolmogorov -Smirnof test. The changes after each evaluation will be analyzed with the t-student test and with an ANOVA of repeated measures, the intra and intersubject effect will be observed. The effect size will be calculated using Cohen's formula. An improvement in the strength, stability and asymmetries of the lower limbs in soccer players is expected.
The purpose of the study is to compare overall response rate (ORR) between treatment groups in participants with higher-risk Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML) who are not eligible for Hematopoietic Stem Cell Transplantation (HSCT).
In contrary to what is seen in FRT cells, rectal organoids of patients with a R334W mutation do respond to CFTR modulators ivacaftor and lumacaftor. The present study will investigate the response to modulators in organoids of 30 patients with CF and a R334W mutation, to allow further stratificaton for a future clinical trial assessing the clinical effect of ivacaftor/tezacaftor in patients with CF and a R334W mutation.
Primary Objective: • To compare the immunogenicity of Gan & Lee Insulin Lispro Injection and EU-authorized Humalog following treatment in adult subjects with T1DM Secondary Objectives: - To evaluate the safety of Gan & Lee Insulin Lispro Injection in comparison with that of EU authorized Humalog following treatment in adult subjects with T1DM - To evaluate the efficacy of Gan & Lee Insulin Lispro Injection in comparison with that of EU authorized Humalog following treatment in adult subjects with T1DM
Spinal Cord Injury (SCI) is an involvement of the spinal cord, a nerve cord protected by the spine and extends from the base of the brain to the lumbar region. The spinal cord lesion causes complete or incomplete paralysis of voluntary mobility and absence, partial or total, of any sensitivity below the affected area; In addition, it also involves the lack of control over the sphincters of urination and intestinal evacuation, disorders of sexuality and fertility, alterations of the Vegetative Nervous System and risk of suffering other complications not less important as: bedsores, spasticity, kidney processes, ... The cervical and dorsal cord injury severely affects respiratory function due to paralysis and deterioration of the respiratory muscles. Several types of respiratory muscle training (RMT) have been described to improve respiratory function for people with SCI in the literature. Despite the relatively small number of studies included in this review, the meta-analysis of the pooled data indicates that RMT would be effective in increasing respiratory muscle strength and also lung volumes for people with SCI. More research is needed to obtain functional results after EMR, such as dyspnea, cough efficacy, respiratory complications, hospital admissions due to respiratory complications and quality of life.
To investigate the effectiveness and tolerability of a second maintenance treatment in participants with platinum-sensitivity relapsed (PSR) epithelial ovarian cancer, who have previously received PARPi maintenance treatment and who have benefit (complete response [CR] or partial response [PR]) or stable disease (SD) from further platinum based chemotherapy.
The purpose of this study is to determine whether ceftolozane-tazobactam is as effective as meropenem with respect to 30 day mortality in the treatment of bloodstream infection due to third-generation cephalosporin non-susceptible Enterobacterales or a known chromosomal AmpC-producing Enterobacterales (Enterobacter spp., Citrobacter freundii, Morganella morganii, Providencia spp. or Serratia marcescens).