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NCT ID: NCT06051409 Recruiting - Ph+ ALL Clinical Trials

A Study of Olverembatinib in Patients With Newly Diagnosed Ph+ALL.

Start date: August 31, 2023
Phase: Phase 3
Study type: Interventional

A global multicenter, open-label, randomized and registrational Phase 3 study to evaluate efficacy and safety of Olverembatinib combined with chemotherapy versus Imatinib combined with chemotherapy in subjects with newly diagnosed Ph+ALL.

NCT ID: NCT06051357 Active, not recruiting - Clinical trials for Paroxysmal Nocturnal Hemoglobinuria

Proof of Concept Study to Assess the Efficacy, Safety of HRS-5965 in Patients With Paroxysmal Nocturnal Hemoglobinuria

Start date: November 15, 2023
Phase: Phase 2
Study type: Interventional

This is a multicenter, randomized, open-label phase II clinical trial. A total of 24 patients with paroxysmal nocturnal hemoglobinuria naïve to complement inhibitor therapy were included. Subjects were treated with HRS-5965 for 12 weeks.

NCT ID: NCT06051266 Recruiting - Edentulous Jaw Clinical Trials

Accuracy of Dynamic Navigation and Static Template in Completely Edentulous Patients

Start date: April 1, 2023
Phase: N/A
Study type: Interventional

The study was a prospective, multicentre, randomized parallel controlled clinical trial. Randomisation was conducted by central randomisation, with random allocation codes generated by the main central computer. Enrollment was conducted by competition between different centres. In this study, the coronal, apical and angular deviations (mean, standard deviation, median, quartiles, minimum, maximum, 95% confidence interval) of the static template and dynamic navigation group guided implant placement were calculated. The data is proposed to be analysed using a mixed linear effects model.

NCT ID: NCT06050980 Recruiting - NSCLC Clinical Trials

Phase I Study of HSK40118 in NSCLC Patients With EGFR Mutation

Start date: March 27, 2023
Phase: Phase 1
Study type: Interventional

This is a phase I, open-label, dose-escalation and expansion study to evaluate the safety, tolerability, PK and PD of HSK40118 when given orally in patients with active EGFR mutation locally advanced or metastatic non-small cell lung cancer (NSCLC). The study will contain two phase: Phase Ia is dose escalation phase and Phase Ib is dose expansion phase.

NCT ID: NCT06050629 Completed - Clinical trials for Elasticum, Incomplete Pseudoxanthoma

The Characteristics of Backscattering With Depth in the Progression of Keratoconus

Start date: January 1, 2020
Phase:
Study type: Observational

To investigate the variation in backscattering with depth between forme fruste keratoconus (FFKC), keratoconus, and normal eyes; to determine the backscattering changes in the characteristics of keratoconus progression; and to explore the diagnostic value of backscattering in FFKC.

NCT ID: NCT06050460 Recruiting - COVID-19 Clinical Trials

SA55 Injection: a Potential Therapy for the Prevention and Treatment of COVID-19

Start date: June 15, 2023
Phase: Phase 1
Study type: Interventional

In this first-in-humans dose escalation study, SA55 will be evaluated for safety, tolerability, and pharmacokinetics. The study is intended to enable future studies of SA55-injection's efficacy in preventing and treating COVID-19.

NCT ID: NCT06050317 Recruiting - Pancreas Cancer Clinical Trials

Sintilimab Combined With Chemotherapy and Radiotherapy in Patients With Inoperable Pancreatic Cancer

Start date: August 18, 2023
Phase: Phase 2
Study type: Interventional

Hypothesis: Survival benefits could be found in Sintilimab plus chemotherapy and radiotherapy in patients with inoperable pancreatic cancer.

NCT ID: NCT06050239 Recruiting - Clinical trials for Metastatic Prostate Cancer

Study of 177Lu-PSMA-0057 in Metastatic Prostate Cancer

Start date: March 1, 2023
Phase: Early Phase 1
Study type: Interventional

The purpose of this study is to evaluate the effectiveness and safety of 177Lu-PSMA-0057 in metastatic prostate cancer.

NCT ID: NCT06050226 Recruiting - Clinical trials for Paroxysmal Nocturnal Hemoglobinuria

A Study of MY008211A in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Start date: July 6, 2023
Phase: Phase 2
Study type: Interventional

The main purpose of this study is to evaluate the efficacy of MY008211A in adult patients with PNH , showing signs of active hemolysis, in China.

NCT ID: NCT06050109 Recruiting - Clinical trials for Breast Cancer Female

The Benefits of Continued Use of Ovarian Function Suppression After 5 Years

Start date: September 1, 2023
Phase:
Study type: Observational

To observe and evaluate the clinical efficacy and safety of continuous use of OFS for premenopausal patients with early breast cancer after 5 years use of OFS. This study is a multicenter, prospective, observational, non randomized controlled, open-label real world study based on hospital medical record system data, aimed at evaluating the benefits of continuing to use OFS after 5 years of use. The retrospective analysis plan includes patient data from September 1, 2023 to September 1, 2026. Join two cohorts: the continued use group and the discontinued use group after 5 years of OFS, respectively.