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NCT ID: NCT04490512 Completed - HPV Infection Clinical Trials

Study of FluBHPVE6E7 in HPV-16 Infected Women

Start date: December 9, 2020
Phase: Phase 1
Study type: Interventional

BS-01 is a randomised, double-blind, placebo-controlled, phase 1 dose escalation study assessing safety, tolerability and immunogenicity of FluBHPVE6E7, changes in the HPV infection status and cervical cytology, and biodistribution in HPV-16 infected women with normal cytology, CIN1 or CIN2. The safety and immunogenicity of two dose levels, 7.5 log10 and 9.0 log10 fTCID50/dose of FluBHPVE6E7 are assessed after three subcutaneous administrations. In addition the safety of 9.0 log10 fTCID50/dose of FluBHPVE6E7 is assessed after three intradermal or intramuscular administrations.

NCT ID: NCT04486209 Completed - Multiple Sclerosis Clinical Trials

Non-invasive Spinal Cord Stimulation for Spasticity Control and Augmentation of Voluntary Motor Control in Individuals With Multiple Sclerosis

noSpasMS
Start date: December 27, 2017
Phase: Early Phase 1
Study type: Interventional

Epidural spinal cord stimulation (SCS) is currently regarded as one of the most promising intervention methods to improve motor function in individuals with severe spinal cord injury. In parallel, an increasing number of studies is suggesting that noninvasive SCS can improve spasticity and residual motor control in the same subject population. The present study explores whether single sessions of noninvasive SCS would improve walking performance and ameliorate spasticity in individuals with multiple sclerosis.

NCT ID: NCT04484740 Completed - Clinical trials for Infection, Bacterial

Penetration of the Innovative Antibiotic Gepotidacin Into Prostate and Tonsillar Tissue

AB-Direct
Start date: January 29, 2021
Phase: Phase 1
Study type: Interventional

Gepotidacin is a new antibiotic that may potentially be used to treat prostatic infections and pharyngeal gonorrhoea. To date, no data exists on gepotidacin pharmacokinetics in those tissues. The present study is being carried out to determine concentrations of gepotidacin in plasma, prostate and tonsillar tissue of patients undergoing radical prostatectomy (RPE) for localized prostate, simple prostatectomy (PE) for benign prostate hyperplasia (BPH) or tonsillectomy (TE). This will contribute to a more complete understanding of the drug's penetration to its site of action.

NCT ID: NCT04482049 Completed - Clinical trials for Fatty Acid Oxidation Disorder

A Prospective Study of the Disease Characteristics of Adult Patients With Long Chain Fatty Acid Oxidation Disorders

FORWARD
Start date: January 15, 2021
Phase:
Study type: Observational

The purpose of the study is to collect information on disease characteristics from adult patients diagnosed with fatty acid oxidation disorders (FAOD).

NCT ID: NCT04480840 Completed - Clinical trials for Primary Sclerosing Cholangitis

Phase 2a Evaluation of Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Patients With Primary Sclerosing Cholangitis (PSC)

Start date: July 27, 2020
Phase: Phase 2
Study type: Interventional

A Phase 2a, multicenter, randomized, double-blind, dose-ranging, placebo-controlled, study to evaluate the safety, tolerability, and PK of PLN-74809 in participants with primary sclerosing cholangitis and suspected liver fibrosis

NCT ID: NCT04474678 Completed - Leukemia Clinical Trials

Quality Improvement Project - "My Logbook! - I Know my Way Around!"; ("Mein Logbuch - Ich Kenne Mich Aus!")

Start date: September 7, 2020
Phase: N/A
Study type: Interventional

In this study, the main goal is to implement and evaluate a novel, evidence-based psycho-educative program for children in oncological care. Patients are provided with booklets tailored to each specific stage of their treatment. Among other factors, children's emotional well-being is evaluated as well as feasibility. The study is carried out at multiple sites across Austria, Germany and Italy/South Tirol.

NCT ID: NCT04472039 Completed - Clinical trials for Macular Edema, Cystoid

Intraretinal Cystoid Changes After Vitrectomy With Membrane Peeling

Start date: June 30, 2020
Phase:
Study type: Observational

Aim of the study is to assess the rate of postoperative intraretinal cystoid changes after pars plana vitrectomy with membrane peeling and peribulbar application of triamcinolone acetonide and to examine possible risk factors for postoperative intraretinal cystoid changes.

NCT ID: NCT04471116 Completed - Vaginal Microbiome Clinical Trials

Influence of Probiotics on the Vaginal Microbiota

Start date: March 30, 2018
Phase: N/A
Study type: Interventional

The study aims to assess the influence of a probiotic supplement (OMNi-BiOTiC® FLORA plus +) on the vaginal microbiome composition of women suffering from infertility.

NCT ID: NCT04456998 Completed - Clinical trials for Pulmonary Artery Hypertension

GB002 in Adult Subjects With Pulmonary Arterial Hypertension (PAH)

Start date: November 12, 2020
Phase: Phase 2
Study type: Interventional

The primary objective for this trial is to determine the effect of GB002 (seralutinib) on improving pulmonary hemodynamics in subjects with World Health Organization (WHO) Group 1 PAH who are Functional Class (FC) II and III. The secondary objective for this trial is to determine the effect of GB002 (seralutinib) on improving exercise capacity in this population.

NCT ID: NCT04450407 Completed - Clinical trials for Type 1 Diabetes Mellitus

A Study of LY3209590 in Participants With Type 1 Diabetes

Start date: July 6, 2020
Phase: Phase 2
Study type: Interventional

The reason for this study is to see if the study drug LY3209590 is safe and effective in participants with type 1 diabetes.