Corynebacterium Infections Clinical Trial
Official title:
Corynebacterium Spp Bone and Joint Infection: Retrospective Study of Microbiological, Diagnostic and Therapeutic Features
Corynebacterium spp have been considered as innocuous commensals of human skin, but are now
accepted as important opportunistic pathogens responsible for various nosocomial infections,
especially implicating foreign materials. In particular, they accounted for up to 10% of
prosthetic joint infection (PJI), and are mostly identified in chronic forms of bone and
joint infections (BJI). However, little is known about the pathophysiological pathway
implicated in Corynebacterium BJI, species distribution and antimicrobial susceptibility, and
the management of these difficult-to-treat clinical entities.
This study aims to report a retrospective cohort of patients with Corynebacterium spp BJI,
aiming to : i) describe microbiological characteristics of the implicated clinical isolates,
including species identification and antimicrobial susceptibility (and especially according
to previous antimicrobial exposure); ii) assess pathophysiological mechanisms associated with
BJI chronicity, including biofilm formation and bone cell invasion, to better understand
mechanisms of Corynebacterium spp and to evaluate their ability to distinguished colonizing
and infective isolates; iii) describe the medical (nature and duration of antimicrobial
therapy) and surgical management of these patients; and iv) evaluate the patient outcome
according to this management strategy, and highlight risk factor for treatment failure in
order to improve patient's management.
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