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Cortisol clinical trials

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NCT ID: NCT05760872 Recruiting - Cortisol Clinical Trials

Effect of MIST on Esophageal Sensitivity: Pilot Study

PilotMIST
Start date: November 4, 2021
Phase:
Study type: Observational

Influence of placing the esophageal probe on the cortisol response. Number of cortisol (non)responders and association of heart rate and subjective perception of stress with cortisol levels.

NCT ID: NCT04563676 Recruiting - Covid19 Clinical Trials

Physiopathology and Sequelae of COVID-19 Infection

SEQ-COV-PHYSIO
Start date: September 22, 2020
Phase: N/A
Study type: Interventional

The data obtained from Covid-19 infections seem to suggest that the immunogenesis of Covid-19 could in some cases be the result of immune dysregulation. On the other hand, endocrine damage is possible at the tile of Covid-19 infection (mainly thyroid,adrenal, and hypothalamus). These disorders are autoimmune or linked to degeneration. The main objective is to assess the thyroid function (thyrotropic axis) as well as the corticotropic adrenal function of patients who have had Copvid-19 pneumonia. The secondary objectives is to describe the pathophysiological mechanisms of pulmonary and vasculothrombotic involvement of Covid-19

NCT ID: NCT04514731 Recruiting - Arthropathy of Knee Clinical Trials

Magnesium Sulfate and Neuroendocrine Hormone

Start date: January 21, 2021
Phase: Phase 4
Study type: Interventional

Total knee arthroplasty is a procedure that relieves pain in patients with severe symptomatic osteoarthritis, but it can be associated with postoperative pain, which hinders recovery. In the previous study, we reported evidence of increased pain in patients undergoing staged total knee arthroplasty, in whom the second operated knee had greater sensitivity (tertiary hyperalgesia) as a result of the surgical injury to the first operated knee. Magnesium sulfate is an effective analgesic adjuvant for postoperative pain. Its analgesic property seems to be associated with the regulation of calcium influx into the cells, or antagonism of N-methyl-D-aspartate receptors in the central nervous system. Additionally, magnesium is known to have an anti-inflammatory effect. Inflammatory state may accompany with pain via peripheral or central sensitization. Recently, we reported that magnesium sulfate effectively attenuates not only postoperative pain but also increased pain intensity without serious adverse effects in the bilateral staged total knee arthroplasty. However, the exact mechanism regarding these effects of magnesium sulfate remains unclear. In the present study, we will investigate the analgesic mechanism of magnesium sulfate via analysis of endocrine neurosteroid levels in patients undergoing bilateral staged total knee arthroplasty.

NCT ID: NCT03554694 Recruiting - Anxiety Clinical Trials

Gut-brain Axis, Brain Function, and Behaviour.

Start date: May 6, 2018
Phase: N/A
Study type: Interventional

The aim is to test if dietary supplementation with prebiotics reduces measures of anxiety in healthy human participants with high self-reported levels of anxiety. Study will test for an effect on behavioural, neuroendocrine and brain imaging markers of anxiety.

NCT ID: NCT03530943 Recruiting - Clinical trials for Anxiety Disorders and Symptoms

Pet Partners for Promotion of Academic Life Skills

Pet PALS
Start date: August 2016
Phase: N/A
Study type: Interventional

The current study utilized a randomized controlled trial, conducted in a real-life setting, to determine whether, how, under which conditions, and for whom, infusing various levels of human-animal interaction (HAI) in a 4-week, university-based stress prevention program provides an effective approach to prevent negative ramifications of university students stress, promote student executive functioning and learning, while safeguarding animal welfare. This study will examine effects of sole exposure to evidence-based stress prevention content, hands-on HAI with registered PET Partner teams, or combinations thereof on students' moment-to-moment well-being and longer-term functioning in socioemotional, cognitive and physiological domains.This study will also develop a comprehensive coding system and measure the dynamic nature of behavior of participants, handlers and animals during university- based animal assisted activities, as well as the HAI environment. The data and analyses will then be utilized to inform the development of a quantitative measure to capture of the quality of human animal interaction in various settings to experimentally determine causal pathways underlying program effects on humans and animals.

NCT ID: NCT02187328 Recruiting - Cortisol Clinical Trials

Effects of Fruit Juices on Hormone Metabolism

Start date: June 2014
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether grapefruit juice alters the metabolism of cortisol following intense exercise.