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Clinical Trial Summary

This is a randomized, double-blind placebo-controlled trial to investigate the efficacy and safety of tradipitant 85 mg orally given twice daily to treat inflammatory lung injury associated with severe or critical COVID-19 infection.

On evaluation for enrollment, participant will need to meet all inclusion and exclusion criteria. If participant consents, they will be randomized 1:1 to treatment with either tradipitant 85 mg PO BID or placebo in addition to standard of care for COVID-19 infection as per the protocol at the treating hospital. NEWS 2 will be assessed at screening and daily following randomization. Inflammatory lab markers as detailed should be collected once per day in the morning, preferably at the same time every morning. All enrolled participants will have whole blood collected for whole genome sequencing.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04326426
Study type Interventional
Source Vanda Pharmaceuticals
Contact
Status Enrolling by invitation
Phase Phase 3
Start date April 13, 2020
Completion date August 31, 2020

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