Coronary Syndrome Clinical Trial
— PLAQUEOfficial title:
Identification of Innovative Circulating and Cellular Biomarkers in Subjects With Acute and Chronic Coronary Syndrome (PLAQUE Study)
The study will to test the levels of innovative biomarkers, such as miRNAs, in the blood of subjects underwent to angioplasty procedure according to standard clinical practice.
Status | Recruiting |
Enrollment | 20 |
Est. completion date | April 30, 2024 |
Est. primary completion date | April 30, 2024 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Clinical indication for the PCI procedure according to the latest ESC (European Society of Cardiology) Guidelines - Coronary stenosis treated with angioplasty must be located in the proximal segments of the three main vessels: IVA, CX and CD - The vessels must have a diameter of their mid-distal section = 3 mm - Patients with NSTEMI ACS and clinical indication with favorable anatomy for coronary angioplasty, also called percutaneous coronary intervention (PCI), (for the ACS group) - Patients with clinically incipient SCC with stable angina (or significant anginal equivalents) and clinical indication with favorable anatomy for PCI (for the SCC group) Exclusion Criteria: - Contraindications to anticoagulant/antiplatelet therapy - Extensive calcifications and/or tortuosity of the major epicardial segments - Evidence of thrombotic occupation - Patients with hemodynamic instability - Patients with EF (ejection fraction) < 35% - Patients with severe chronic renal failure (e-GFR < 30 mL/min) |
Country | Name | City | State |
---|---|---|---|
Italy | IRCCS INRCA Hospital | Ancona |
Lead Sponsor | Collaborator |
---|---|
Istituto Nazionale di Ricovero e Cura per Anziani | Ministry of Health, Italy |
Italy,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | miRNome analysis | The Next Generation Sequencing (NGS) techniques will be used to identify miRNome picture as potential biomarkers for acute and chronic coronary syndrome. | baseline | |
Secondary | Identification of biomarkers of inflammation | Interleukin-6 and soluble ST2 levels will be assessed in plasma samples. | baseline |
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