Coronary Stenosis Clinical Trial
Official title:
An Open-label, Single-centre Study Evaluating the Prevalence and Characteristics of Coronary and Cerebrovascular Arteriosclerosis as Measured by Combined Coronary and Cerebral Angiography, and Comparing the Efficacy and Safety of Simultaneous or Staged Coronary and Cerebral Interventional Strategy in Chinese Patients
Intracranial atherosclerosis is common vascular lesion in Asian acute stroke patients and
intracranial atherosclerosis patients have high rate of coronary artery disease (CAD).
Moreover, several studies showed obvious association of CAD and cerebrovascular stenosis,
which had been proved to increase the risk of stroke after coronary revascularization
including coronary bypass surgery or percutaneous coronary intervention. In addition, the
efficacy and safety of combined coronary and cerebral intervention are not fully
investigated. Hence, the aim of this study is to evaluate the prevalence and characteristics
of coronary and cerebrovascular arteriosclerosis as measured by combined coronary and
cerebral angiography, explore the relationship between inflammation, atherosclerosis-related
markers and coronary and cerebral atherosclerosis and compare the efficacy and safety of
simultaneous or staged coronary and cerebral interventional strategy in Chinese Patients.
The coronary angiography and cerebrovascular angiography are performed for all participants.
The combined strategy for coronary and cerebrovascular angiography is carried out routinely
in the investigators institutions. Simultaneous strategy is considered as that performed via
the same access and within the same day. Staged strategy is intended as that performed
within 7 days from the first procedure. The sequence of angiographies is established on an
individual patient basis by the cardiovascular and neurointerventional team according to
clinical symptoms of the patients and after coronary or cerebrovascular angiography. After
combined coronary and cerebral angiography, simultaneous or staged interventional strategy
will be performed in patients with severe coronary and cerebral stenosis. Blood sample is
obtained from artery sheath when performing coronary or cerebral angiography. Lipid levels,
inflammation and atherosclerosis-related markers will be measured in this study.
n/a
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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