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Impact of Pumps on Internal Thoracic Arteries (IPITA) — IPITA  

Coronary Disease Clinical Trial

Official title:
Cardiopulmonary Bypass and Internal Thoracic Arteries: Can Roller or Centrifugal Pumps Change Vascular Reactivity of the Grafts

Clinical Trial Summary

Cardiopulmonary bypass (CPB) induces a systemic inflammatory response and affects the organ vascular bed. Experimentally, the lack of pulsatility alters myogenic tone of resistance arteries and increases the parietal inflammatory response. The purpose of this study was to compare the vascular reactivity and the inflammatory response of the internal thoracic arteries (ITAs) between patients undergoing coronary artery bypass grafting (CABG) under CPB with a roller pump or with a centrifugal pump.

Clinical Trial Description

Eighty elective male patients undergoing CABG were selected using one or two internal thoracic arteries under CPB with a roller pump (RP group) or centrifugal pump (CFP group). ITA samples were collected before starting CPB (Time 1) and before the last coronary anastomosis during aortic cross clamping (Time 2). Terminal complement complex activation (SC5b-9) and neutrophil activation (elastase) analysis were performed on arterial blood at the same times. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04168853
Study type Interventional
Source University Hospital, Angers
Contact
Status Completed
Phase N/A
Start date November 3, 2015
Completion date December 8, 2017
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