Different Endurance Training Protocols in Cardiac Patients

Coronary Artery Disease Clinical Trial

Official title:

Effects of Different Endurance Training Protocols on Physical Performance in Cardiac Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02303379
• Other study ID #: UISM-8
• Status: Completed
• Phase: N/A
• Start date: January 2014
• Est. completion date: December 2020

Study information

• Verified date: January 2021
• Source: Paracelsus Medical University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

It is the aim of our study to compare the effects of 6 and/or 2 years of either HIT (carried out at correctly assessed 85-95% of maximal heart rate), pyramid, or continuous endurance training, on changes of physical exercise capacity in cardiac patients.

Description:

The three exercise arms (isocaloric) are composed as follows:

Endurance training: 31 min at 65-75% HRmax, making it a total of 25min; HIT: 4x4min intervals at 85-95% HRmax divided by 3x3min of active recovery at 60-70% HRmax, making it a total of 25 min; Pyramid: One pyramid consists of 8 one-minute blocks. Those are grouped starting with one block of 70-75% HRmax, followed by one block at 75-80% HRmax and another one at 80-85% HRmax. The top of the pyramid are 2 blocks of 85-90% HRmax. Intensity is lowered afterwards with one block of 80-85% HRmax, followed by one block at 75-80% HRmax and last one at 70-75% HRmax. Two more pyramids follow, each divided by 2min of active recovery at 65-70% HRmax, making it a total of 28min.

All protocols are initiated by 5min of warm-up and end with 5min of cool-down, both at 60-70% HRmax.

Primary Outcome: Individual maximum power output in watt (Pmax). Secondary Outcome: Change of power output in watt at lactate tresholds at 2 and 4mmol/l.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 52
• Est. completion date: December 2020
• Est. primary completion date: December 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• acute coronary syndrome (STEMI - NONSTEMI)

• aortocoronary bypass surgery

• percutaneous coronary intervention (PCI)

• state after stable coronary heart disease

• state after heart surgeries

• state after myo-, endo-, or pericarditis

• state after heart- or lung-transplantation

• state after heart failure

• state after pulmonary hypertension

• state after peripheral venous disease

• state after electrophysiological surgery

• state after implantation of an implantable cardioverter or difibrillator

• Patients at high risk

• Patients with cardiac dysrhythmias or sudden death

Exclusion Criteria:

• unstable angina pectoris

• Heart failure (NYHA IV)

• acute myo-, endo-, or pericarditis or other infections

• pulmonary-arterial embolism or phlebothrombosis within 6 months

• hemodynamic instable dysrhythmias

• hypertrophic cardiomyopathy

• medical conditions which prevent patients from complying with the exercise program

Related Conditions & MeSH terms

• Coronary Artery Disease

Intervention

Other:
• Continuous Endurance Training
Endurance training with constant work load 31min at 65-75% Hrmax
• Pyramid Training
One pyramid consists of 8 one-minute blocks. Those are grouped starting with one block of 70-75% HRmax, followed by one block at 75-80% HRmax and another one at 80-85% HRmax. The top of the pyramid are 2 blocks of 85-90% HRmax. Intensity is lowered afterwards with one block of 80-85% HRmax, followed by one block at 75-80% HRmax and last one at 70-75% HRmax. Two more pyramids follow, each divided by 2min of active recovery at 65-70% HRmax, making it a total of 28min.
• High-intensity interval training
HIT: 4x4 min intervals at85-95% HRmax divided by 3x3min of active recovery at 60-70% HRmax, making it a total of 25min.

Locations

Country	Name	City	State
Austria	Department of Sports Medicine, Prevention and Rehabilitation Paracelsus Medical University	Salzburg

Sponsors (1)

Lead Sponsor	Collaborator
Paracelsus Medical University

Country where clinical trial is conducted

Austria, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Physical work capacity (PWC)	PWC will be measured by graded exercise testing on cycle ergometer.	6 weeks or 36 weeks
Secondary	Heart rate	Heart rate will be measured by graded exercise testing on cycle ergometer.	6 weeks or 36 weeks
Secondary	Blood pressure	Blood pressure will be measured by graded exercise testing on cycle ergometer.	6 weeks or 36 weeks
Secondary	Lactate Thresholds	Lactate thresholds will be measured by graded exercise testing on cycle ergometer.	6 weeks or 36 weeks
Secondary	Metabolical and cellular blood parameter	Blood will be taken before and after intervention	6 weeks or 36 weeks
Secondary	BMI	BMI will be taken before and after intervention	6 weeks or 36 weeks
Secondary	Gene expression	Gene expression will be taken before and after intervention	6 weeks or 36 weeks
Secondary	Quality of Life	Quality of Life will be taken before and after intervention	6 weeks or 36 weeks

External Links

•   Department of Sports Medicine, Prevention and Rehabilitation Paracelsus Medical University
•   Paracelsus Medical University Salzburg, Austria
•   Salzburg Regional Hospital