Painless Subconjunctival Antibiotic and Antifungal Injection in Corneal Ulcer Patients

Corneal Ulcer Clinical Trial

Official title:

Painless Subconjunctival Antibiotic and Antifungal Injection in Corneal Ulcer Patients.

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00789646
• Other study ID #: SI 271/2008
• Status: Terminated
• Phase: N/A
• Start date: June 2008
• Est. completion date: June 2009

Study information

• Verified date: March 2019
• Source: Mahidol University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The propose of this study is to determine the efficacy of 2% xylocaine in reducing pain due to subconjunctival antibiotic and antifungal injection.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 10
• Est. completion date: June 2009
• Est. primary completion date: December 2008
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• The corneal ulcer patients who are diagnosed by ophthalmologist and have 2 of 3 in these following features.

1. corneal epithelial defect with stromal infiltration

2. reaction in anterior chamber

3. positive for bacteria or fungus

• The patients have to receive subconjunctival antibiotic injection twice at least.

• The patients must be informed consent.

Exclusion Criteria:

• The patients who have history of allergy of local anesthetics, antibiotics or antifungal drugs.

• The patients who administered NSAIDs or weak opioids within 24 hours prior to subconjunctival antibiotic/antifungal injection.

• Unable to cooperate with the treatment.

• Pregnant women

Related Conditions & MeSH terms

• Corneal Ulcer
• Ulcer

Intervention

Procedure:
• Lidocaine/NSS
First injection: subconjunctival 2% lidocaine without adrenaline 0.4 ml. before antibiotic injection Second injection (24 hours later): subconjunctival NSS 0.4 ml. before antibiotic injection
• NSS/Lidocaine
First injection: subconjunctival NSS 0.4 ml. before antibiotic injection Second injection (24 hours later): subconjunctival 2% lidocaine without adrenaline 0.4 ml. before antibiotic injection

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Mahidol University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Numeric rating scale		immediately after injection
Secondary	Side effects		24 hours after injection