Clinical Trials Logo
  1. Home
  2. Corneal Diseases
  3. NCT00810472

Functional Antigen Matching in Corneal Transplantation — FANCY  

Corneal Diseases Clinical Trial

Official title:
Clinical Trial to Investigate Superiority of HLA Matching in Comparison to Random Graft Assignment With Respect to the Endpoint 'Time to First Endothelial Graft Rejection' in Penetrating Keratoplasty.

Clinical Trial Summary

Penetrating keratoplasty is one of the most commonly performed transplantation surgeries. Graft rejection is a major complication. HLA compatibility has already been demonstrated an effective prophylaxis in several retrospective investigations. The purpose of the investigators randomized clinical trial is to demonstrate superiority of HLA matching in comparison to random graft assignment with respect to the endpoint 'time to first endothelial graft rejection' in penetrating keratoplasty. The investigators will perform DNA-based allele resolution typing.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00810472
Study type Interventional
Source University Hospital Freiburg
Contact
Status Completed
Phase N/A
Start date September 2009
Completion date May 2015
View Details
See also
  Status Clinical Trial Phase
Completed NCT02291731 - Autologous Serum Eye Drops With Contact Lenses for Corneal Epithelial Defects N/A
Completed NCT00029185 - Study of Dehydrex in Patients With Corneal Erosion N/A
Enrolling by invitation NCT03436576 - Efficacy of Two Concentrations of Autologous Serum for the Treatment of Severe Dry Eye Phase 3
Completed NCT02344732 - Effect of Systemic Oxygen on Corneal Epithelial Wound Healing in Diabetic Patients Undergoing Pars Plana Vitrectomy N/A
Not yet recruiting NCT05833737 - Corneal Findings in Patients Treated With Belantamab Mafodotin
Completed NCT04421300 - A Randomized Study of Smile Exercise for Dry Eye N/A
Completed NCT00396188 - Screening Aid to Identify Corneas That May Have Pathologies or Other Conditions Phase 1
Terminated NCT03029104 - Collagen Cross-Linking With Ultraviolet-A in Asymmetric Corneas Phase 2
Completed NCT02348242 - Ocular Surface Disorders in Patients in Intensive Care Units, a Comparative Study of Three Preventive Approaches N/A
Completed NCT00050466 - Dynamic Light Scattering and Keratoscopy for Corneal Examination N/A
Recruiting NCT04164407 - Keratoconus, Corneal Diseases and Transplant Registry
Withdrawn NCT05052554 - Study With QR-504a to Evaluate Safety, Tolerability & Corneal Endothelium Molecular Biomarker(s) in Subjects With FECD3 Phase 1
Terminated NCT00447187 - Study to Assess the Efficacy and Safety of LX201 for Prevention of Corneal Allograft Rejection Episodes and Graft Failure in Subjects at Increased Immunological Risk Phase 3
Completed NCT00491439 - Using in Vivo Confocal Microscope to Evaluate the Corneal Wound Healing After Various Ocular Surgeries N/A