Menthol for Dyspnea Relief in Health and COPD — MENTHODYSC  

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title: Effectiveness and Mechanisms of Menthol Inhalation for the Relief of Dyspnea in Health and COPD

Status Recruiting

Clinical Trial Summary

Menthol inhalation (MI) is a novel and promising treatment option for acute relief of dyspnea, however, the underlying ventilatory and/or neural related mechanisms for this relief in symptoms remain unknown. The overall aim of this research project is to systematically examine the mechanisms of dyspnea relief from MI in healthy individuals and those with COPD.

Clinical Trial Description

The project is structured in 4 work packages (WP), each including a different sample of healthy volunteers (WP1, 2) or patients with COPD (WP3, 4), respectively with a 1:1 female/male ratio in each WP. Each WP will be single-blind, placebo-controlled cross-over trial to investigate the effects of MI compared to placebo in healthy volunteers during resistive loaded breathing (WP1), in healthy volunteers during cycling exercise (WP2), in people with COPD who have dyspnea at rest (WP3), and in people with COPD during cycling exercise (WP4). ;

Related Conditions & MeSH terms

• Chronic Obstructive Pulmonary Disease
• Dyspnea
• Lung Diseases, Obstructive
• Pulmonary Disease, Chronic Obstructive

• NCT number: NCT05785026
• Study type: Interventional
• Source: KU Leuven
• Contact: Daniel Langer
• Phone: +32 16 37 64 97
• Email: daniel.langer@kuleuven.be
• Status: Recruiting
• Phase: N/A
• Start date: January 1, 2023
• Completion date: June 30, 2027