Resting Heart Rate in Chronic Obstructive Pulmonary Disease

COPD Clinical Trial

Official title:

Improvement of Resting Heart Rate After Exercise Training and Its Predictors in Chronic Obstructive Pulmonary Diseases

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04890080
• Other study ID #: IKC111
• Status: Completed
• Phase: N/A
• Start date: January 2017
• Est. completion date: April 2021

Study information

• Verified date: May 2021
• Source: Izmir Katip Celebi University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

110 COPD patients who were participated in the PR program were included in the study. Resting Heart Rate , pulmonary functions, functional capacity, perception of dyspnea, quality of life and psychological symptoms compared before and after PR.

Description:

In many studies, it has been reported that baroreceptor activity and heart rate variability decrease and resting heart rate (RHR) increases in COPD patients due to changes in cardiac autonomic function. Among the recommendations regarding pulmonary rehabilitation (PR) and exercise training in COPD patients, approaches such as including practices targeting RHR and developing implementation strategies that improve the cardiovascular system are recommended. The primary aim of our study is to examine the effect of comprehensive exercise training consisting of breathing, aerobic and strengthening exercises on RHR in COPD patients, and secondarily to determine the factors that affect RHR change after PR in COPD patients.

110 COPD patients who were participated in the PR program were included in our retrospective study. Resting Heart Rate , pulmonary functions, functional capacity, perception of dyspnea, quality of life and psychological symptoms compared before and after PR.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 110
• Est. completion date: April 2021
• Est. primary completion date: December 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients diagnosed with COPD according to GOLD and completed the 2-day / 8-week PR program

Exclusion Criteria:

• With cardiovascular disease

• With additional diseases such as diabetes

• Receiving medical treatment that affects the autonomic nervous system

• Patients receiving long-term oxygen therapy

Related Conditions & MeSH terms

• COPD
• Exercise
• Lung Diseases, Obstructive
• Pulmonary Disease, Chronic Obstructive
• Pulmonary Rehabilitation
• Resting Heart Rate

Intervention

Other:
• Pulmonary Rehabilitation
Exercise training consisted of supervised breathing, aerobic, strengthening and stretching exercises for 8 weeks, 2 days a week. Breathing exercises included pursed lip, diaphragmatic, thoracic expansion and basal expansion exercises. Strength training included the lower and upper extremities, and it was performed 8-10 repetitions, either against gravity or using free weight, according to patient tolerance.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Izmir Katip Celebi University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Resting Heart Rate	number of beats per minute	1 minute
Secondary	Functional Capacity	Six Minute- walk test	Change from baseline six minute walk distance at 8 week
Secondary	Dyspnea Assessment	Medical Research Council Scale(MRC); the MRC dyspnea scale is a questionnaire that consists of five statements about perceived breathlessness. (min 1- max 5 point) Higher scores mean a worse outcome.	Change from baseline dyspnea at 8 week
Secondary	Quality of Life Assessment	St. George Respiratory Questionnaire; Scores range from 0 to 100, with higher scores indicating more limitations.	Change from baseline dyspnea at 8 week
Secondary	Anxiety and Depression	Hospital Anxiety and Depression (HAD); The HADS questionnaire has seven items each for depression and anxiety subscales. Scoring for each item ranges from zero to three, with three denoting highest anxiety or depression level. A total subscale score of >8 points out of a possible 21 denotes considerable symptoms of anxiety or depression.	Change from baseline dyspnea at 8 week