Ventilator Asynchrony as a Predictor of Weaning Failure

Chronic Obstructive Pulmonary Disease(COPD) Clinical Trial

Official title:

Patient Ventilator Asynchrony as a Predictor of Weaning Failure in Mechanically Ventilated COPD Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04735497
• Other study ID #: Ventilator Asynchrony
• Status: Completed
• Start date: February 15, 2018
• Est. completion date: December 20, 2019

Study information

• Verified date: February 2021
• Source: Assiut University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Patient ventilator asynchrony is a common problem in mechanically ventilated patients .It is associated with adverse effects including increased work of breathing, patient discomfort, increased need for sedation, prolonged mechanical ventilation , weaning difficulties and weaning failure. 100 mechanically ventilated COPD patients were enrolled in this prospective study .Detection of patient ventilator asynchrony was done on 30-minute sessions at 12, 24, 36, and 48 hours following intubation by visual assessment of pressure, flow and volume graphs on ventilator .

Description:

Patient-ventilator asynchrony is defined as a lack of organization between the patient and ventilator timing of both inspiration and expiration . It is a commonly reported problem during mechanical ventilation. Thille et al. found that 24% of patients developed asynchrony in at least ten percent of their breaths, moreover they stated that the most frequent asynchronies was each of ineffective triggering and double triggering . Eighty percent of chronic obstructive pulmonary disease (COPD) patients experienced ineffective triggering, where it is considered the most frequent asynchrony in this group of patients. Asynchrony between Patient and ventilator also leads to prolonged duration of invasive ventilation, and increase possibility of weaning failure.

Both spread and intensity of asynchrony during the early phase of weaning in COPD patients has never satisfactorily described. The aim of the current study was to describe the patient-ventilator asynchrony and its impact on weaning outcome in mechanically ventilated COPD patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: December 20, 2019
• Est. primary completion date: August 15, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

All COPD patients who were diagnosed after history ,physical examination radiology and pulmonary function tests and required mechanical ventilation.

Exclusion Criteria:

1. Age < 18 years

2. Tracheostomy

3. Failure to trigger breaths even in cases of receiving neuromuscular blocking agents.

4. Encephalopathy which is not caused by hypercapnia or hypoxemia either post arrest or due to cerebrovascular stroke

5. Patients with unplanned weaning

6. COPD patients where intubation not related to exacerbation e.g. acute pulmonary edema.

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Related Conditions & MeSH terms

• Chronic Obstructive Pulmonary Disease(COPD)
• Lung Diseases, Obstructive
• Pulmonary Disease, Chronic Obstructive

Locations

Country	Name	City	State
Egypt	Assuit University Hospital	Assuit

Sponsors (1)

Lead Sponsor	Collaborator
Reham Mohammed Elmorshedy

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To study effect of different types of ventilator asynchrony on weaning in mechanically ventilated COPD patients	Detection of patient ventilator asynchrony was done on 30-minute sessions following intubation by visual assessment of pressure, flow; and volume graphs on ventilator .Repeated measures are done from the begining of mechanical ventilation and type of asynchronies including ineffective trigger double trigger, auto trigger , delayed cycle, early cycle and flow asynchrony. were recorded.	One year