Low-load Blood Flow Restriction Training in COPD

COPD Clinical Trial

— LL-BFRT COPD  

Official title:

Low-load Blood Flow Restriction Training in COPD

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04151771
• Other study ID #: 2019-01641
• Secondary ID: SNCTP00000350920
• Status: Completed
• Phase: N/A
• Start date: December 27, 2019
• Est. completion date: January 28, 2023

Study information

• Verified date: April 2023
• Source: University of Zurich
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Peripheral muscle weakness is a predominant problem in patients with COPD and treated using exercise training in pulmonary rehabilitation. Despite pulmonary rehabilitation being an effective intervention, muscle strength impairment is a persisting problem in COPD patients. Patients have problems to tolerate the high training loads, which are necessary to develop strength. Low-load blood flow restriction training (LL-BFRT) might therefore be an option to enhance muscular response of patients with COPD to strength training. Up to now, no studies investigating LL-BFRT in respiratory diseases are available.

The primary outcome of this randomized pilot study is knee extensor muscle strength. Secondary, the study will evaluate if LL-BFRT is well tolerated and feasible in COPD patients attending outpatient pulmonary rehabilitation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: January 28, 2023
• Est. primary completion date: January 28, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 40 Years and older

Eligibility

Inclusion Criteria:

• Diagnosed COPD according to GOLD-guidelines

• Assigned to outpatient pulmonary rehabilitation by the treating physician

Exclusion Criteria:

• Physical or intellectual impairment precluding informed consent or protocol adherence

• Non-German speaking (precluding informed consent)

• Acute or recent (within the last 6 weeks) exacerbation of COPD

• Attending a pulmonary rehabilitation program within the last 3 months

• Pregnant patients

• History of thromboembolic event in the lower extremity

• Diagnosis of polyneuropathy

• Resting systolic blood pressure <100 mmHg

Related Conditions & MeSH terms

• COPD
• Muscle Weakness
• Paresis

Intervention

Other:
• Low-load blood flow restriction training
The intervention group will perform the exercises of the lower limbs using LL-BFRT with an occlusion pressure of 70% of arterial occlusion pressure with low training loads (30% of the 1 repetition maximum).
• Usual outpatient pulmonary rehabilitation
The control group will perform outpatient pulmonary rehabilitation as established.

Locations

Country	Name	City	State
Switzerland	University Hospital Zurich	Zurich

Sponsors (1)

Lead Sponsor	Collaborator
University of Zurich

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Knee extensor strength	Between-group difference in total change in isometric muscle strength of the knee extensor muscles, measured by handheld dynamometry in newtonmeter	during 12 weeks (24 exercise sessions)