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O2 Transport and Utilization in Health and Lung Disease

COPD Clinical Trial

Official title:
Role of Nitric Oxide Coupling in Muscle Dysfunction With COPD

Clinical Trial Summary

Skeletal muscle dysfunction is a frequent and clinically relevant systemic manifestation of Chronic Pulmonary Obstructive Disease (COPD), which is still poorly understood. Therefore, the focus of this study is on the role of a deficit in tetrahydrobiopterin and nitric oxide synthase uncoupling induced by chronic oxidative stress on metabolic and vascular abnormalities in skeletal muscle of patients suffering from COPD.

Clinical Trial Description

The purpose of this study is to assess the efficacy of supplementation with tetrahydrobiopterin (BH4) for improving vascular and muscle function in patients with COPD and healthy controls. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04014712
Study type Interventional
Source University of Massachusetts, Amherst
Contact
Status Withdrawn
Phase Phase 1
Start date April 2021
Completion date August 2022
View Details
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