The Effect of Humidification on Mucus Rheology

Chronic Obstructive Pulmonary Disease(COPD) Clinical Trial

Official title:

The Effect of Humidification on Mucus Rheology

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01661374
• Other study ID #: HM14433
• Status: Completed
• Phase: N/A
• First received: August 6, 2012
• Last updated: December 9, 2014
• Start date: July 2012
• Est. completion date: April 2014

Study information

• Verified date: December 2014
• Source: Virginia Commonwealth University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

In this study the investigators will collect mucus from mechanical ventilated patients and patients with COPD to study the effect of temperature and humidity, on the biophysical properties of the airway mucus. It is hypothesised that changes in inspired gas temperature and humidity (over time) may affect the biophysical properties of the airway mucus and reduce the airway's ability to clear mucus, resulting in deleterious clinical affects.

Description:

Expectorated sputum samples are collected and used to measure the biophysical properties of mucus secretions. The samples are later exposed to different temperatures and humidity levels during bench experiments.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 18
• Est. completion date: April 2014
• Est. primary completion date: April 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 40 Years to 90 Years

Eligibility

Mechanically Ventilated Patients

Inclusion Criteria:

Any Subject Mechanically Ventilated and producing sputum.

Exclusion

COPD Group

Inclusion Criteria:

• 40 to 90 years of age suffering from COPD

• History of mucus production

Exclusion Criteria:

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Chronic Obstructive Pulmonary Disease(COPD)
• Lung Diseases, Obstructive
• Pulmonary Disease, Chronic Obstructive

Locations

Country	Name	City	State
United States	Virginia Commonwealth University	Richmond	Virginia

Sponsors (2)

Lead Sponsor	Collaborator
Virginia Commonwealth University	Fisher and Paykel Healthcare

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Sputum Collection	Sputum is collected during pulmonary function test (PFT) to later measure the biophysical properties of sputum.	10 minutes	No