COPD Clinical Trial
This study, a new immunomodulatory therapy of COPD with vasoactive intestinal peptide (VIP)
was evaluated. Based on preliminary unpublished clinical and experimental results, the
course of disease under VIP treatment and the molecular mechanisms involved were assessed.
34 patients with severe COPD were treated either with VIP inhalation in addition to
conventional therapy or inhalation of placebo plus conventional therapy for a period of 3
months. The trial was conducted as a double blind, comparative study with two parallel
groups.
Chronic obstructive bronchitis is a chronic inflammatory disease of the airways, which
affects as many as 8% of individuals in industrialized nations. There is an increase in the
number of woman and men suffering from COPD. Pulmonary hypertension and cor pulmonale are
common sequelae of chronic airflow obstruction, but the precise mechanisms of increased
vascular resistance are unclear. Potential causes of pulmo-nary hypertension in COPD include
emphysematous destruction of the capillary bed, remodeling of pulmonary vessels and hypoxic
pulmonary vasoconstriction. This proposal, a new immunomodulatory therapy of COPD with
vasoactive intestinal peptide (VIP) was evaluated. Based on preliminary unpublished clinical
and experimental results, the course of disease under VIP treatment and the molecular
mechanisms involved were assessed.
34 patients with severe COPD were treated either with VIP inhalation in addition to
conventional therapy or inhalation of placebo plus conventional therapy for a period of 3
months. The trial was conducted as a double blind, comparative study with two parallel
groups.
In the absence of acute infection or acute worsening of the disease due to other conditions,
2 transbronchial biopsies were collected before treatment, and after 3 months of treat¬ment
for assessment of the regulation of a) the immune response, b) the extracellular matrix and
c) the epithelial growth. This assessment will be performed in fully equipped and
experienced laboratories at the University of Vienna.
;
Allocation: Random Sample, Time Perspective: Longitudinal
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