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Clinical Trial Summary

Menthol inhalation (MI) is a novel and promising treatment option for acute relief of dyspnea, however, the underlying ventilatory and/or neural related mechanisms for this relief in symptoms remain unknown. The overall aim of this research project is to systematically examine the mechanisms of dyspnea relief from MI in healthy individuals and those with COPD.


Clinical Trial Description

The project is structured in 4 work packages (WP), each including a different sample of healthy volunteers (WP1, 2) or patients with COPD (WP3, 4), respectively with a 1:1 female/male ratio in each WP. Each WP will be single-blind, placebo-controlled cross-over trial to investigate the effects of MI compared to placebo in healthy volunteers during resistive loaded breathing (WP1), in healthy volunteers during cycling exercise (WP2), in people with COPD who have dyspnea at rest (WP3), and in people with COPD during cycling exercise (WP4). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05785026
Study type Interventional
Source KU Leuven
Contact Daniel Langer
Phone +32 16 37 64 97
Email daniel.langer@kuleuven.be
Status Recruiting
Phase N/A
Start date January 1, 2023
Completion date June 30, 2027

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