Arterial and End-Tidal CO2 Gradient as a Mortality Predictor in Critical Care Patients

Copd Clinical Trial

Official title:

Arterial and End-Tidal CO2 Gradient as a Mortality Predictor in Critical Care Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05341258
• Other study ID #: 3751
• Status: Completed
• Phase: N/A
• Start date: January 1, 2022
• Est. completion date: August 1, 2022

Study information

• Verified date: November 2021
• Source: Gaziosmanpasa Research and Education Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Scoring systems (SOFA, APACHE-II etc.) are used to estimate the mortality rates of patients treated in the intensive care unit. . In the scoring systems used, the disfunction level of the organs of the patients is measured. Blood gas analysis is routinely performed in patients whom intubated in the intensive care unit and receiving mechanical ventilation support, and the patient's treatment is optimized according to the results of the examination. The patient's mechanical ventilation settings are regulated by analyzing the Partial Arterial Carbondioxide (paCO2) value in the patient's blood gas result. The difference between the paCO2 value in the blood gas and the End-tidal Carbondioxide (EtCO2) value measured in the mechanical ventilator is 3-5mmHg in normal healthy people, while this difference is seen more in critical care patients. In critically ill patients in the intensive care unit, there is a greater increase in the difference between paCO2 and ETCO2 in cases where mortality is high, such as global perfusion disorder, shock situations, and massive pulmonary embolism, etc. In this study, it was planned to investigate the use of the difference between the paCO2 value in the blood gas taken from the patient and the ETCO2 value measured in the mechanical ventilator to predict the mortality rate of the patient.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: August 1, 2022
• Est. primary completion date: August 1, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Critical Care Patients intubated in last 24 hours.

Exclusion Criteria:

• Patients younger than 18 years old.

Related Conditions & MeSH terms

• Copd
• Critical Illness
• Embolism
• Pulmonary Embolism
• Shock
• Trauma
• Ventilation Perfusion Mismatch

Intervention

Diagnostic Test:
• EtCO2
EtCO2
• PaCO2
PaCO2

Locations

Country	Name	City	State
Turkey	Gaziosmanpasa Training Research Hospital	Istanbul

Sponsors (1)

Lead Sponsor	Collaborator
Gaziosmanpasa Research and Education Hospital

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Mortality	Evaluation of correlation between PaCO2 and ETCO2 gradient difference and mortality in intubated critical care patients and mortality rates	6 months
Secondary	ICU Length of Stay	Days patients treated at ICU	6 months
Secondary	Ventilator Free Days	Days during which the patient was mechanically ventilated	6 months