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Clinical Stabilization of Hypercapnia: NIPPV v HVNI — HYPERACT  

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title:
Hypercapnia Clinical Efficacy by NIPPV v HVNI: A Randomized Control Trial in the Stabilization of Acute Hypercarbic Respiratory Failure

Clinical Trial Summary

This study will evaluate the ability of High Velocity Nasal Insufflation [HVNI] to effect ventilation and related physiologic responses in hypercapnic patients when compared to noninvasive positive pressure ventilation [NIPPV].

Clinical Trial Description

The overall objective of this randomized study is to evaluate the efficacy of HVNI, in comparison to NIPPV, to clinically stabilize and provide respiratory therapy to patients who have COPD with moderate-to-severe hypercapnic respiratory distress upon presentation. It is hypothesized that HVNI is comparable to NIPPV in the stabilization and relief of moderate-to-severe hypercapnic respiratory distress upon presentation, by relieving the patient's dyspnea (breathlessness) within 4 hours to a comparable degree to NIPPV. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04709562
Study type Interventional
Source Vapotherm, Inc.
Contact
Status Active, not recruiting
Phase N/A
Start date November 11, 2020
Completion date December 22, 2023
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