COPD Clinical Trial
Official title:
Effects of Continuous Chest Wall Vibration on Dyspnea and Exercise Tolerance in COPD Patients
Dyspnea, the sensation of breathing discomfort or shortness of breath, is one of the main
symptoms for patients affected by Chronic Obstructive Pulmonary Disease (COPD), particularly
during exercise. Previous study show that chest wall vibration decrease dyspnea in COPD
patients and precisely when applied during the inspiration phase, called "in-phase vibration"
(IPV) which provide vibration directly on intercostal muscles. These findings have been
obtained in laboratory context and the intercostals muscles vibration has been tested only in
single phases of breathing, during inspiration with IPV and during exhalation with
out-of-phase vibration (OPV). None study has evaluated the effect of a continuous chest wall
vibration (CCWV), namely muscles vibration during the whole cycle of breathing, on dyspnea in
patients with COPD in a clinical context. Continuous high frequency vibration has been proven
to reduce myoelectrical manifestation of fatigue, probably modifying the centrally driven
motor unit recruitment hierarchy, in healthy subjects.
Moreover, CCWV is a modality of provide vibration more suitable and cost-effective in a
clinical context than single-phases vibration that requires specific instruments for the
detection of breathing phases and the coupling with vibration device.
On these bases, the investigators hypothesized that CCWV at high frequency, applied during a
cycle ergometer training program, could decrease dyspnea and enhance the exercise tolerance
in COPD patients. Therefore, the aim of this study is to evaluate the effects of high
frequency CCWV on dyspnea and exercise tolerance in patients with COPD patients compared to
usual care and to sham intervention.
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