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On Demand Contraception: Ulipristal Acetate Plus a COX-2 Inhibitor at Peak Fertility

Contraception Clinical Trial

Official title:
On Demand Contraception: Investigating Efficacy of Ulipristal Acetate Plus a COX-2 Inhibitor at Peak Fertility

Clinical Trial Summary

This is an exploratory prospective study investigating if addition of a COX-2 inhibitor can increase efficacy of ulipristal in disrupting ovulation at peak fertility.

Clinical Trial Description

This is an exploratory prospective study investigating if addition of a COX-2 inhibitor can increase efficacy of ulipristal in disrupting ovulation at peak fertility. We will compare the proportion of women with ovulatory disruption after taking the study medications with those women's own placebo cycles and also to previously established/published rates of ovulatory disruption of ulipristal alone.9 Given the established efficacy of ulipristal during the follicular time period as well as the theoretical mechanism of meloxicam to disrupt cumulus-oocyte expansion is a late step in ovulation, we hypothesize that this medication could emerge as the best candidate for an oral on-demand contraceptive option. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03354117
Study type Interventional
Source Stanford University
Contact
Status Completed
Phase Phase 1
Start date March 15, 2018
Completion date May 31, 2019
View Details
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