Congenital Uterine Anomalies Clinical Trial
Official title:
Prevalence of Congenital Uterine Malformations in Women With a History of Preterm Delivery or Miscarriage
Aims: We plan to investigate how common uterine malformations are in high-risk women (with history of miscarriage or preterm delivery), by analysing different characteristics in these groups. This study will also investigate other ultrasound characteristics detected on these women. This study will point towards the possible mechanism of how uterine malformations may affect pregnancy outcomes.
Background: Congenital abnormally shaped wombs (uterine malformations) have long been
thought to be more common in women with poor pregnancy outcomes, e.g. miscarriage (Rackow
and Arici 2007) and preterm delivery (Tomazevic, Ban-Frangez et al. 2007). However, the true
prevalence is difficult to assess as there are no universally agreed classification systems
and some of the best investigations are invasive. In addition, previous prevalence studies
have not examined the details of subfertility or pregnancy loss, such as duration of
subfertility, the gestation of pregnancy loss, or miscarriage pattern.
Aims: We plan to investigate how common uterine malformations are in high-risk women (with
history of miscarriage or preterm delivery), by analysing different characteristics in these
groups. This study will also investigate other ultrasound characteristics detected on these
women. This study will point towards the possible mechanism of how uterine malformations may
affect pregnancy outcomes.
Methods: We plan to recruit women who have had miscarriage or preterm delivery into our
study. A sample of women who had normal term deliveries will be recruited as comparison. All
women will undergo one 3-dimensional ultrasound scan each.
Outcomes: The proportions of women with congenital uterine malformations will be determined.
Any ultrasound-detected markers found especially in women with poor pregnancy outcomes may
point towards how uterine malformations affect pregnancies.
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Observational Model: Case Control, Time Perspective: Prospective