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Effect of Exendin-(9-39) on Fasting Adaptation and Protein Sensitivity

Congenital Hyperinsulinism Clinical Trial

Official title:
Role of GLP-1 in Congenital Hyperinsulinism:Effect of Exendin-(9-39) on Fasting Adaptation and Protein Sensitivity

Clinical Trial Summary

The purpose of this study is to examine the effects of exendin-(9-39) on fasting blood glucose and protein induced hypoglycemia on subjects with Congenital Hyperinsulinism. Funding Source - FDA Office of Orphan Products Development (OODP).

Clinical Trial Description

This is a placebo controlled study with randomized crossover design to evaluate the effect of the glucagon-like peptide-1 (GLP-1) receptor antagonist, exendin-(9-39), on fasting blood glucose levels, protein-induced hypoglycemia, and fasting tolerance of subjects with congenital hyperinsulinism due to mutations in the ATP- sensitive potassium channel (KATP) channel. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00897676
Study type Interventional
Source Children's Hospital of Philadelphia
Contact
Status Completed
Phase Phase 1/Phase 2
Start date May 2009
Completion date January 2017
View Details
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